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Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6326-6329

2007

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.560-562

2019

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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 2002-03, Vol.45 (6), p.1300-1312

2002

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments

MedChemComm, 2013-11, Vol.4 (11), p.1513

2013

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Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.959-962

2008

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Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (11), p.2724-2729

2016

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Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies

Cancer chemotherapy and pharmacology, 2013-04, Vol.71 (4), p.1021-1032

2013

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A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1

Analytical biochemistry, 2013-09, Vol.440 (1), p.1-5

2013

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Elevated plasma 2‐hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment

British journal of haematology, 2014-07, Vol.166 (1), p.145-148

2014

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ZD4190 : An orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy

Cancer research (Chicago, Ill.), 2000-02, Vol.60 (4), p.970-975

2000

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Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1633-1637

2006

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5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4226-4229

2005

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Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4908-4912

2006

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A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (2), p.674-678

2008

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Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1799-1803

2008

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A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones

Tetrahedron letters, 2012-06, Vol.53 (23), p.2868-2872

2012

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Elevated plasma 2‐hydroxyglutarate in acute myeloid leukaemia: association with the IDH 1 SNP rs11554137 and severe renal impairment

British journal of haematology, 2014-07, Vol.166 (1), p.145-148

2014

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Abstract 1139: Novel, cellular active inhibitors of G6PD, a key mediator of ROS-induced cellular stress

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.1139-1139

2012

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h

2013-10

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Novel 3-alkoxy-1 H-pyrazolo[3,4- d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (3), p.959-962

2008

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Temperature-dependent elaboration of collagenase by the renal adenocarcinoma of the leopard frog, Rana pipiens

Cancer research (Chicago, Ill.), 1984-08, Vol.44 (8), p.3438-3441

1984

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Segregation of structural collagen genes in adolescent idiopathic scoliosis

Clinical orthopaedics and related research, 1992, Vol.274 (274), p.305-310

1992

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Walking, Cloning, and Mapping with YACs in 3q27: Localization of Five ESTs Including Three Members of the Cystatin Gene Family and Identification of CpG Islands

Genomics (San Diego, Calif.), 1996-03, Vol.32 (3), p.425-430

1996

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ChemInform Abstract: Novel 3-Alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 Receptor Tyrosine Kinase Inhibitors

ChemInform, 2008-07, Vol.39 (27), p.no-no

2008

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Collagenase Secretion by Human Breast Neoplasms: A Clinicopathologic Investigation

JNCI : Journal of the National Cancer Institute, 1985-01, Vol.74 (1), p.19-27

1985

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Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure

Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies

A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1

Elevated plasma 2‐hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment

ZD4190 : An orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy

Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket

5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase

Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones

Elevated plasma 2‐hydroxyglutarate in acute myeloid leukaemia: association with the IDH 1 SNP rs11554137 and severe renal impairment

Abstract 1139: Novel, cellular active inhibitors of G6PD, a key mediator of ROS-induced cellular stress

Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h

Novel 3-alkoxy-1 H-pyrazolo[3,4- d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Temperature-dependent elaboration of collagenase by the renal adenocarcinoma of the leopard frog, Rana pipiens

Segregation of structural collagen genes in adolescent idiopathic scoliosis

Walking, Cloning, and Mapping with YACs in 3q27: Localization of Five ESTs Including Three Members of the Cystatin Gene Family and Identification of CpG Islands

ChemInform Abstract: Novel 3-Alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 Receptor Tyrosine Kinase Inhibitors

Collagenase Secretion by Human Breast Neoplasms: A Clinicopathologic Investigation

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