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SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist

Neuropharmacology, 1997-04, Vol.36 (4-5), p.609-620

1997

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SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor

European journal of pharmacology, 1999-06, Vol.375 (1-3), p.359-365

1999

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Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonist

British journal of pharmacology, 2000-08, Vol.130 (7), p.1606-1612

2000

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Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

British journal of pharmacology, 1990-02, Vol.99 (2), p.343-349

1990

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Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue

British journal of pharmacology, 2000-08, Vol.130 (7), p.1597-1605

2000

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5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046) : A potent, selective, and orally bioavailable 5-HT6 receptor antagonist

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.202-205

1999

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(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

Nature (London), 1980-01, Vol.283 (5742), p.92-94

1980

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Pharmacological characterisation of human 5-HT2 receptor subtypes

European journal of pharmacology, 2001-02, Vol.414 (1), p.23-30

2001

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Effect of haloperidol and (−)-sulpiride on dopamine agonist-induced hypoactivity

Neuropharmacology, 1995-04, Vol.34 (4), p.449-455

1995

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Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor

Journal of medicinal chemistry, 1988-06, Vol.31 (6), p.1087-1093

1988

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Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat

Neuropharmacology, 1986-08, Vol.25 (8), p.877-886

1986

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The 5-HT hypothesis of depression revisited

Molecular psychiatry, 1996-12, Vol.1 (6), p.437

1996

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Characterization of the binding of [3H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes

British journal of pharmacology, 1997-08, Vol.121 (8), p.1687-1691

1997

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Influence of peptide CRF receptor antagonists upon the behavioural effects of human/rat CRF

European journal of pharmacology, 1999-06, Vol.373 (2), p.141-145

1999

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Binding of the Novel Serotonin Agonist 8‐Hydroxy‐2‐(Di‐n‐Propylamino) Tetralin in Normal and Alzheimer Brain

Journal of neurochemistry, 1986-03, Vol.46 (3), p.993-996

1986

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1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1863-1866

2000

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Ligands for the investigation of 5-HT autoreceptor function

Brain research bulletin, 2001-11, Vol.56 (5), p.463-469

2001

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1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1867-1870

2000

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Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

Trends in pharmacological sciences (Regular ed.), 1989-04, Vol.10 (4), p.130-132

1989

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Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry

British journal of pharmacology, 1999-04, Vol.126 (7), p.1620-1624

1999

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MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype

Neuroscience letters, 1989-10, Vol.105 (1-2), p.174-176

1989

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In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes

European journal of pharmacology, 1999-04, Vol.370 (1), p.69-77

1999

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The calcium channel activator, Bay K 8644, enhances K+-evoked efflux of acetylcholine and noradrenaline from rat brain slices

Naunyn-Schmiedeberg's archives of pharmacology, 1985-10, Vol.331 (1), p.114-116

MIDDLEMISS, D. N

1985

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5-HT1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo

The Journal of pharmacology and experimental therapeutics, 1994-08, Vol.270 (2), p.656

1994

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Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists

European journal of pharmacology, 1986-01, Vol.120 (1), p.51-56

Middlemiss, Derek N.

1986

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SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist

SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor

Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonist

Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue

5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046) : A potent, selective, and orally bioavailable 5-HT6 receptor antagonist

(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

Pharmacological characterisation of human 5-HT2 receptor subtypes

Effect of haloperidol and (−)-sulpiride on dopamine agonist-induced hypoactivity

Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor

Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat

The 5-HT hypothesis of depression revisited

Characterization of the binding of [3H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes

Influence of peptide CRF receptor antagonists upon the behavioural effects of human/rat CRF

Binding of the Novel Serotonin Agonist 8‐Hydroxy‐2‐(Di‐n‐Propylamino) Tetralin in Normal and Alzheimer Brain

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents

Ligands for the investigation of 5-HT autoreceptor function

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry

MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype

In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes

The calcium channel activator, Bay K 8644, enhances K+-evoked efflux of acetylcholine and noradrenaline from rat brain slices

5-HT1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo

Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists

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