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The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells

Cancer research (Chicago, Ill.), 2003-08, Vol.63 (15), p.4450-4459

2003

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UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation

British journal of pharmacology, 1999-04, Vol.126 (8), p.1707-1716

1999

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The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2163-2167

2004

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Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor

Biochemical and biophysical research communications, 2003-07, Vol.307 (2), p.267-273

2003

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tert -Butyl 4-(1-methyl-1 H -pyrazol-5-yl)piperidine-1-carboxylate

Acta crystallographica. Section E, Structure reports online, 2009-04, Vol.65 (4), p.o870-o870

2009

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Novel CCR1 antagonists with improved metabolic stability

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2175-2179

2004

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Selective addition of amines to 5-trifluoromethyl-2,4-dichloropyrimidine induced by Lewis acids

Tetrahedron letters, 2013-08, Vol.54 (35), p.4610-4612

2013

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Potent small molecule CCR1 antagonists

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2169-2173

2004

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Process Development of CP-481715, a Novel CCR1 Antagonist

Organic process research & development, 2005-07, Vol.9 (4), p.466-471

2005

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Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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ChemInform Abstract: Selective Addition of Amines to 5-Trifluoromethyl-2,4-dichloropyrimidine Induced by Lewis Acids

ChemInform, 2013-12, Vol.44 (52), p.no-no

2013

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tert-Butyl 4-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxyl-ate

Acta crystallographica. Section E, Structure reports online, 2009-03, Vol.65 (Pt 4), p.o870-o870

2009

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Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation

Molecular pharmacology, 1996-12, Vol.50 (6), p.1672-1679

1996

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Daphniphyllum alkaloids. 12. A proposed biosynthesis of the pentacylic skeleton. proto-Daphniphylline

Journal of organic chemistry, 1992-04, Vol.57 (9), p.2554-2566

1992

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Patent focus: inhibitors of tumour cell growth

Expert opinion on therapeutic patents, 2000-06, Vol.10 (6), p.803-818

Kath, John C

2000

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Discovery of (10R)‑7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H‑8,4-(metheno)pyrazolo[4,3‑h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4720-4744

2014

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5-Chloro- N -[2-(1 H -imidazol-4-yl)ethyl]- N -methyl-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine

Acta crystallographica. Section E, Structure reports online, 2010-01, Vol.66 (1), p.o242-o242

2010

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Chapter 18. T Lymphocyte Potassium Channel Blockers

Annual Reports in Medicinal Chemistry, 1997, Vol.32, p.181-190

1997

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Potent Small Molecule CCR1 Antagonists

ChemInform, 2004-09, Vol.35 (36), p.no-no

2004

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The Discovery of Structurally Novel CCR1 Antagonists Derived from a Hydroxyethylene Peptide Isostere Template

ChemInform, 2004-08, Vol.35 (35), p.no-no

2004

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Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials

The Lancet (British edition), 2021-03, Vol.397 (10280), p.1183-1194

2021

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Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care

JAMA pediatrics, 2022-05, Vol.176 (5), p.486

2022

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Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa

The New England journal of medicine, 2014-05, Vol.370 (18), p.1712-1723

2014

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The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells

UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation

The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template

Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor

tert -Butyl 4-(1-methyl-1 H -pyrazol-5-yl)piperidine-1-carboxylate

Novel CCR1 antagonists with improved metabolic stability

Selective addition of amines to 5-trifluoromethyl-2,4-dichloropyrimidine induced by Lewis acids

Potent small molecule CCR1 antagonists

Process Development of CP-481715, a Novel CCR1 Antagonist

ChemInform Abstract: Selective Addition of Amines to 5-Trifluoromethyl-2,4-dichloropyrimidine Induced by Lewis Acids

tert-Butyl 4-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carboxyl-ate

Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation

Daphniphyllum alkaloids. 12. A proposed biosynthesis of the pentacylic skeleton. proto-Daphniphylline

Patent focus: inhibitors of tumour cell growth

5-Chloro- N -[2-(1 H -imidazol-4-yl)ethyl]- N -methyl-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine

Chapter 18. T Lymphocyte Potassium Channel Blockers

Potent Small Molecule CCR1 Antagonists

The Discovery of Structurally Novel CCR1 Antagonists Derived from a Hydroxyethylene Peptide Isostere Template

Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials

Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care

Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa

Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett's esophagus: a multi-center case-control study

Outcome of intracerebral hemorrhage associated with different oral anticoagulants

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