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Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection

Carcinogenesis (New York), 1989-05, Vol.10 (5), p.827-832

1989

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Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats

Drug metabolism and disposition, 1997-03, Vol.25 (3), p.362

1997

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[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

Methods in Enzymology, 1990, Vol.186, p.521-530

1990

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Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.1041-1046

2000

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Bioavailability and metabolism of cidofovir following topical administration to rabbits

Antiviral research, 1997-07, Vol.35 (2), p.113-122

1997

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Clinical Pharmacokinetics of 1-[((S)-2-Hydroxy-2-Oxo-1,4,2-Dioxaphosphorinan-5-yl)methyl]cytosine in Human Immunodeficiency Virus-Infected Patients

Antimicrobial Agents and Chemotherapy, 1999-02, Vol.43 (2), p.271-277

1999

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Oral Formulations of Adefovir Dipivoxil: In Vitro Dissolution and in Vivo Bioavailability in Dogs

Journal of pharmaceutical sciences, 1997-12, Vol.86 (12), p.1334-1338

1997

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Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis

Clinical pharmacology and therapeutics, 1999, Vol.65 (1), p.21-28

1999

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Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1898-1906

2005

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Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs

International journal of pharmaceutics, 1995-10, Vol.125 (1), p.91-97

1995

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Isolation and identification of a metabolite of cidofovir from rat kidney

Journal of pharmaceutical and biomedical analysis, 1998-04, Vol.16 (8), p.1349-1356

1998

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Aryl ester prodrugs of cyclic HPMPC. I : Physicochemical characterization and in vitro biological stability

Pharmaceutical research, 1999-11, Vol.16 (11), p.1687-1693

1999

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XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.324-333

2004

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Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys

Pharmaceutical research, 1994-06, Vol.11 (6), p.839-843

1994

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Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis

Journal of ocular pharmacology and therapeutics, 1998-04, Vol.14 (2), p.147-151

1998

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Efficacy of Gabapentin Enacarbil vs Placebo in Patients with Postherpetic Neuralgia and a Pharmacokinetic Comparison with Oral Gabapentin

Pain medicine (Malden, Mass.), 2011-07, Vol.12 (7), p.1098-1108

2011

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Determination of allopurinol and oxypurinol in rat plasma, intestinal wash, and bile by high-performance liquid chromatography with electrochemical detection (HPLC/EC) following automated solid phase extraction

Pharmaceutical research, 1991-05, Vol.8 (5), p.653-655

1991

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XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.315-323

2004

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In vitro characteristics of guinea pig lung aromatic azaheterocycle N-methyltransferase

Drug metabolism and disposition, 1985-11, Vol.13 (6), p.658

1985

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Stereospecific in vivo N-methylation of nicotine in the guinea pig

Drug metabolism and disposition, 1985-03, Vol.13 (2), p.175

1985

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A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome

Clinical neuropharmacology, 2012-07, Vol.35 (4), p.165-173

2012

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High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine

Journal of chromatography, 1984-01, Vol.306, p.291-301

1984

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Evidence of stereospecificity in the in vivo methylation of [14C](+/-)-nicotine in the guinea pig

Drug metabolism and disposition, 1984-11, Vol.12 (6), p.755

1984

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High-performance liquid chromatographic determination of cytosine-containing compounds by precolumn fluorescence derivatization with phenacyl bromide: application to antiviral nucleosides and nucleotides

Journal of chromatography. B, Biomedical applications, 1996-04, Vol.679 (1), p.119-127

1996

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A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers

International journal of clinical pharmacology and therapeutics, 2011-02, Vol.49 (2), p.109-115

2011

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Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection

Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats

[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1

Bioavailability and metabolism of cidofovir following topical administration to rabbits

Clinical Pharmacokinetics of 1-[((S)-2-Hydroxy-2-Oxo-1,4,2-Dioxaphosphorinan-5-yl)methyl]cytosine in Human Immunodeficiency Virus-Infected Patients

Oral Formulations of Adefovir Dipivoxil: In Vitro Dissolution and in Vivo Bioavailability in Dogs

Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis

Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs

Isolation and identification of a metabolite of cidofovir from rat kidney

Aryl ester prodrugs of cyclic HPMPC. I : Physicochemical characterization and in vitro biological stability

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys

Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys

Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis

Efficacy of Gabapentin Enacarbil vs Placebo in Patients with Postherpetic Neuralgia and a Pharmacokinetic Comparison with Oral Gabapentin

Determination of allopurinol and oxypurinol in rat plasma, intestinal wash, and bile by high-performance liquid chromatography with electrochemical detection (HPLC/EC) following automated solid phase extraction

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters

In vitro characteristics of guinea pig lung aromatic azaheterocycle N-methyltransferase

Stereospecific in vivo N-methylation of nicotine in the guinea pig

A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome

High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine

Evidence of stereospecificity in the in vivo methylation of [14C](+/-)-nicotine in the guinea pig

High-performance liquid chromatographic determination of cytosine-containing compounds by precolumn fluorescence derivatization with phenacyl bromide: application to antiviral nucleosides and nucleotides

A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers

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