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Mitotane has a strong and a durable inducing effect on CYP3A4 activity

European journal of endocrinology, 2011-04, Vol.164 (4), p.621-626

2011

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Extensions to the Visual Predictive Check to facilitate model performance evaluation

Journal of pharmacokinetics and pharmacodynamics, 2008-04, Vol.35 (2), p.185-202

2008

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Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

Therapeutic drug monitoring, 2009-04, Vol.31 (2), p.187-197

2009

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Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

DRUG METABOLISM AND PHARMACOKINETICS, 2009-01, Vol.24 (1), p.3-15

2009

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Pharmacokinetic-Pharmacodynamic Model for the Reversal of Neuromuscular Blockade by Sugammadex

Anesthesiology (Philadelphia), 2009, Vol.110 (1), p.95-105

2009

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Exposure–Response Modeling and Simulation of Progression‐Free Survival and Adverse Events of Sorafenib Treatment in Patients With Advanced Thyroid Cancer

Clinical and translational science, 2019-09, Vol.12 (5), p.459-469

2019

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Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar

Journal of clinical pharmacology, 2013-03, Vol.53 (3), p.256-263

2013

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Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake

British journal of clinical pharmacology, 2020-12, Vol.86 (12), p.2362-2376

2020

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Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation

British journal of clinical pharmacology, 2022-02, Vol.88 (2), p.734-741

2022

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Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview

Clinical pharmacokinetics, 2022-01, Vol.61 (1), p.1-16

2022

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Phase 1 dose-escalation and pharmacokinetic study of regorafenib in paediatric patients with recurrent or refractory solid malignancies

European journal of cancer (1990), 2021-08, Vol.153, p.142-152

2021

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Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study

Clinical cancer research, 2023-11, Vol.29 (21), p.4341-4351

2023

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Trends in pharmacological sciences (Regular ed.), 2008-04, Vol.29 (4), p.186-191

2008

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The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

Drug discovery today, 2013-09, Vol.18 (17-18), p.853-862

2013

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Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study

EClinicalMedicine, 2023-04, Vol.58, p.101917-101917, Article 101917

2023

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Model‐Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms

Journal of clinical pharmacology, 2017-05, Vol.57 (5), p.640-651

2017

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Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.357-400

2007

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Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Journal of pharmacological and toxicological methods, 2013-05, Vol.67 (3), p.203-213

2013

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Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1367-1378

2014

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Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration

Drug metabolism and disposition, 2011-12, Vol.39 (12), p.2275-2282

2011

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Exploring genetic and non‐genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

British journal of clinical pharmacology, 2016-07, Vol.82 (1), p.227-237

2016

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Population Pharmacokinetic Analysis for Simultaneous Determination of B max and K D In Vivo by Positron Emission Tomography

Molecular imaging and biology, 2005-11, Vol.7 (6), p.411-421

2005

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Marginal increase of sunitinib exposure by grapefruit juice

Cancer chemotherapy and pharmacology, 2011-03, Vol.67 (3), p.695-703

2011

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Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

Journal of pharmacokinetics and pharmacodynamics, 2012-10, Vol.39 (5), p.463-477

2012

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Nonlinear Mixed Effects Modeling of the Diurnal Blood Pressure Profile in a Multiracial Population

American journal of hypertension, 2013-09, Vol.26 (9), p.1103-1113

2013

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Mitotane has a strong and a durable inducing effect on CYP3A4 activity

Extensions to the Visual Predictive Check to facilitate model performance evaluation

Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

Pharmacokinetic-Pharmacodynamic Model for the Reversal of Neuromuscular Blockade by Sugammadex

Exposure–Response Modeling and Simulation of Progression‐Free Survival and Adverse Events of Sorafenib Treatment in Patients With Advanced Thyroid Cancer

Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar

Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake

Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation

Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview

Phase 1 dose-escalation and pharmacokinetic study of regorafenib in paediatric patients with recurrent or refractory solid malignancies

Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study

Model‐Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms

Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration

Exploring genetic and non‐genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

Population Pharmacokinetic Analysis for Simultaneous Determination of B max and K D In Vivo by Positron Emission Tomography

Marginal increase of sunitinib exposure by grapefruit juice

Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

Nonlinear Mixed Effects Modeling of the Diurnal Blood Pressure Profile in a Multiracial Population

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