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NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

Hypertension (Dallas, Tex. 1979), 2019-06, Vol.73 (6), p.1300-1307

2019

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Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

The FASEB journal, 2012-12, Vol.26 (12), p.5161-5171

2012

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Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2012-08, Vol.60 (2), p.411-418

2012

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New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5748-5763

2014

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Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

The Journal of neuroscience, 2014-01, Vol.34 (3), p.1057-1066

2014

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Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure: A New Strategy for Treating Hypertension

Hypertension (Dallas, Tex. 1979), 2008-05, Vol.51 (5), p.1318-1325

2008

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Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

Hypertension (Dallas, Tex. 1979), 2008-02, Vol.51 (2, part 2), p.460-465

2008

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Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (20), p.7775-7780

2004

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Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

Hypertension (Dallas, Tex. 1979), 2007-03, Vol.49 (3, Part 2 Suppl), p.625-630

2007

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Cytoskeletal Genes Regulation by Chronic Morphine Treatment in Rat Striatum

Neuropsychopharmacology, 2004-12, Vol.29 (12), p.2208-2215

2004

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Intrarenal Aminopeptidase N Inhibition Restores Defective Angiontesin II Type 2-Mediated Natriuresis in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2010-02, Vol.55 (2), p.474-480

2010

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Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats

American journal of physiology. Regulatory, integrative and comparative physiology, 2003-03, Vol.284 (3), p.725-R733

2003

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Chronic Morphine Treatment Modulates the Extracellular Levels of Endogenous Enkephalins in Rat Brain Structures Involved in Opiate Dependence: A Microdialysis Study

The Journal of neuroscience, 2002-02, Vol.22 (3), p.1034-1041

2002

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Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats

Addiction biology, 2012-05, Vol.17 (3), p.528-538

2012

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Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain

Neuroscience letters, 2003-07, Vol.345 (2), p.77-80

2003

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Roles of brain angiotensins II and III in thirst and sodium appetite

Brain research, 2005-10, Vol.1060 (1), p.108-117

2005

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Rat Hippocampal Neurons Are Critically Involved in Physiological Improvement of Memory Processes Induced by Cholecystokinin-B Receptor Stimulation

The Journal of neuroscience, 1999-08, Vol.19 (16), p.7230-7237

1999

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Aminopeptidase A Inhibitors as Potential Central Antihypertensive Agents

Proceedings of the National Academy of Sciences - PNAS, 1999-11, Vol.96 (23), p.13415-13420

1999

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Partial Protection against Botulinum B Neurotoxin-Induced Blocking of Exocytosis by a Potent Inhibitor of Its Metallopeptidase Activity

Chembiochem : a European journal of chemical biology, 2005-08, Vol.6 (8), p.1375-1380

2005

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Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus

Neuropharmacology, 2007-02, Vol.52 (2), p.430-435

2007

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Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone

Pain (Amsterdam), 2003-07, Vol.104 (1-2), p.139-148

2003

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Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells

Journal of medicinal chemistry, 1997-11, Vol.40 (24), p.3947-3956

1997

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Long Lasting Antinociceptive Properties of Enkephalin Degrading Enzyme (NEP and APN) Inhibitor Prodrugs

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3523-3530

2001

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Effects of Dual Angiotensin-Converting Enzyme and Neutral Endopeptidase 24-11 Chronic Inhibition by Mixanpril on Insulin Sensitivity in Lean and Obese Zucker Rats

Journal of cardiovascular pharmacology, 2003-02, Vol.41 (2), p.254-264

2003

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Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Journal of medicinal chemistry, 1999-12, Vol.42 (25), p.5197-5211

1999

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NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure: A New Strategy for Treating Hypertension

Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension

Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

Cytoskeletal Genes Regulation by Chronic Morphine Treatment in Rat Striatum

Intrarenal Aminopeptidase N Inhibition Restores Defective Angiontesin II Type 2-Mediated Natriuresis in Spontaneously Hypertensive Rats

Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats

Chronic Morphine Treatment Modulates the Extracellular Levels of Endogenous Enkephalins in Rat Brain Structures Involved in Opiate Dependence: A Microdialysis Study

Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats

Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain

Roles of brain angiotensins II and III in thirst and sodium appetite

Rat Hippocampal Neurons Are Critically Involved in Physiological Improvement of Memory Processes Induced by Cholecystokinin-B Receptor Stimulation

Aminopeptidase A Inhibitors as Potential Central Antihypertensive Agents

Partial Protection against Botulinum B Neurotoxin-Induced Blocking of Exocytosis by a Potent Inhibitor of Its Metallopeptidase Activity

Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus

Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone

Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells

Long Lasting Antinociceptive Properties of Enkephalin Degrading Enzyme (NEP and APN) Inhibitor Prodrugs

Effects of Dual Angiotensin-Converting Enzyme and Neutral Endopeptidase 24-11 Chronic Inhibition by Mixanpril on Insulin Sensitivity in Lean and Obese Zucker Rats

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

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