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Characterization of efflux transporters involved in distribution and disposition of apixaban

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.827-835

2013

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Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.871-878

2017

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Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.906-915

2013

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Tissue distribution and elimination of [14C]apixaban in rats

Drug metabolism and disposition, 2011-02, Vol.39 (2), p.256-264

2011

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Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor

European journal of drug metabolism and pharmacokinetics, 2011-09, Vol.36 (3), p.129-139

2011

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Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.123-131

2011

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Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.303-315

2008

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Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1341-1356

2008

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Metabolism and excretion of an oral taxane analog, [14C]3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in rats and dogs

Drug metabolism and disposition, 2009-05, Vol.37 (5), p.1115-1128

2009

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Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.150-167

2007

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Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes

Xenobiotica, 2021-01, Vol.51 (1), p.15-23

2021

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Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled MaxiPost (BMS-204352) in humans

Drug metabolism and disposition, 2005-01, Vol.33 (1), p.83-93

2005

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Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.275

2004

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Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans

Drug metabolism and disposition, 2009-08, Vol.37 (8), p.1738

2009

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Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.807-820

2006

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Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.837-845

2003

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In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor

Current drug metabolism, 2006-12, Vol.7 (8), p.883-896

2006

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Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity

Chemical research in toxicology, 2012-03, Vol.25 (3), p.556-571

2012

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Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor

Brain research. Molecular brain research., 1998-07, Vol.58 (1), p.156-169

1998

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Optimization to eliminate the interference of migration isomers for measuring 1-O-β-acyl glucuronide without extensive chromatographic separation

Rapid communications in mass spectrometry, 2008-01, Vol.22 (2), p.109-120

2008

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Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans

Chemico-biological interactions, 1996-10, Vol.102 (2), p.79-92

1996

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Characterization of efflux transporters involved in distribution and disposition of apixaban

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats

Tissue distribution and elimination of [14C]apixaban in rats

Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor

Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs

Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys

Metabolism and excretion of an oral taxane analog, [14C]3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in rats and dogs

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling

Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes

Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled MaxiPost (BMS-204352) in humans

Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension

Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans

Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites

Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats

In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor

Antibody–Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo

Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity

Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor

Optimization to eliminate the interference of migration isomers for measuring 1-O-β-acyl glucuronide without extensive chromatographic separation

Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans

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