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Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

Journal of molecular biology, 2013-04, Vol.425 (8), p.1330-1339

2013

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3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix

Protein engineering, design and selection, 2017-09, Vol.30 (9), p.619-625

2017

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Structural and Functional Analysis of HtrA1 and Its Subdomains

Structure (London), 2012-06, Vol.20 (6), p.1040-1050

2012

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Lead Optimization of a 4‑Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4521-4536

2013

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3186-3194

2013

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A Trigger Squeezed

Structure (London), 2008-03, Vol.16 (3), p.332-334

Eigenbrot, Charles

2008

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Pro-urokinase-type Plasminogen Activator Is a Substrate for Hepsin

The Journal of biological chemistry, 2006-10, Vol.281 (41), p.30439-30446

2006

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An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides

Nature chemical biology, 2014-07, Vol.10 (7), p.567-573

2014

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Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison

Journal of computer-aided molecular design, 2019-03, Vol.33 (3), p.307-330

2019

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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase Inhibitor

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3940-3955

2021

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Design of Organo-Peptides As Bipartite PCSK9 Antagonists

ACS chemical biology, 2020-02, Vol.15 (2), p.425-436

2020

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Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease

Structure (London), 2014-09, Vol.22 (9), p.1333-1340

2014

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Conformational Lability in Serine Protease Active Sites: Structures of Hepatocyte Growth Factor Activator (HGFA) Alone and with the Inhibitory Domain from HGFA Inhibitor-1B

Journal of molecular biology, 2005-03, Vol.346 (5), p.1335-1349

2005

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Engineering Exosite Peptides for Complete Inhibition of Factor VIIa Using a Protease Switch with Substrate Phage

The Journal of biological chemistry, 2003-06, Vol.278 (24), p.21823-21830

2003

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A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

The Journal of biological chemistry, 2005-03, Vol.280 (10), p.9160-9169

2005

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IL-1H, AN INTERLEUKIN 1-RELATED PROTEIN THAT BINDS IL-18 RECEPTOR/IL-1Rrp

Cytokine (Philadelphia, Pa.), 2001-01, Vol.13 (1), p.1-7

2001

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A new regulatory switch in a JAK protein kinase

Proteins, structure, function, and bioinformatics, 2011-02, Vol.79 (2), p.393-401

2011

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A Novel Exosite on Coagulation Factor VIIa and Its Molecular Interactions with a New Class of Peptide Inhibitors

Biochemistry (Easton), 2001-08, Vol.40 (32), p.9522-9531

2001

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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5818-5823

2014

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Convergent Recognition of the IgE Binding Site on the High-Affinity IgE Receptor

Structure (London), 2004-07, Vol.12 (7), p.1289-1301

2004

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A Minimized M13 Coat Protein Defines the Requirements for Assembly into the Bacteriophage Particle

Journal of molecular biology, 2002-09, Vol.322 (2), p.357-367

2002

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Receptor-binding conformation of the "ELR" motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 Å resolution

Proteins, structure, function, and bioinformatics, 2000-03, Vol.38 (4), p.361-367

2000

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Structural Insight into How An Anti-idiotypic Antibody Against D3H44 (Anti-tissue Factor Antibody) Restores Normal Coagulation

Journal of molecular biology, 2003-08, Vol.331 (2), p.433-446

2003

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Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

Cell, 1997-11, Vol.91 (5), p.695-704

1997

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Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix

Structural and Functional Analysis of HtrA1 and Its Subdomains

Lead Optimization of a 4‑Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

A Trigger Squeezed

Pro-urokinase-type Plasminogen Activator Is a Substrate for Hepsin

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides

Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison

Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase Inhibitor

Design of Organo-Peptides As Bipartite PCSK9 Antagonists

Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease

Conformational Lability in Serine Protease Active Sites: Structures of Hepatocyte Growth Factor Activator (HGFA) Alone and with the Inhibitory Domain from HGFA Inhibitor-1B

Engineering Exosite Peptides for Complete Inhibition of Factor VIIa Using a Protease Switch with Substrate Phage

A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

IL-1H, AN INTERLEUKIN 1-RELATED PROTEIN THAT BINDS IL-18 RECEPTOR/IL-1Rrp

A new regulatory switch in a JAK protein kinase

A Novel Exosite on Coagulation Factor VIIa and Its Molecular Interactions with a New Class of Peptide Inhibitors

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Convergent Recognition of the IgE Binding Site on the High-Affinity IgE Receptor

A Minimized M13 Coat Protein Defines the Requirements for Assembly into the Bacteriophage Particle

Receptor-binding conformation of the "ELR" motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 Å resolution

Structural Insight into How An Anti-idiotypic Antibody Against D3H44 (Anti-tissue Factor Antibody) Restores Normal Coagulation

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

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