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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

Cell, 2014-02, Vol.156 (4), p.771-785

2014

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AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

Molecular cell, 2013-03, Vol.49 (6), p.1167-1175

2013

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The Phosphoinositide 3-Kinase Pathway

Science (American Association for the Advancement of Science), 2002-05, Vol.296 (5573), p.1655-1657

Cantley, Lewis C.

2002

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AKT/PKB Signaling: Navigating Downstream

Cell, 2007-06, Vol.129 (7), p.1261-1274

2007

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p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

Cell metabolism, 2012-07, Vol.16 (1), p.104-112

2012

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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Nature medicine, 2015-05, Vol.21 (5), p.457-466

2015

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Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer

Nature reviews. Endocrinology, 2020-05, Vol.16 (5), p.276-283

2020

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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

Molecular cell, 2011-12, Vol.44 (6), p.878-892

2011

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Nature cell biology, 2012-12, Vol.14 (12), p.1295-1304

2012

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The Tumor Suppressor LKB1 Kinase Directly Activates AMP-Activated Kinase and Regulates Apoptosis in Response to Energy Stress

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (10), p.3329-3335

2004

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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Nature cell biology, 2016-05, Vol.18 (5), p.572-578

2016

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Cancer discovery, 2015-11, Vol.5 (11), p.1194-1209

2015

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Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation

Molecular cell, 2013-10, Vol.52 (2), p.161-172

2013

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Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm

Oncogene, 2015-09, Vol.34 (36), p.4702-4712

2015

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Targeting the PI3K-Akt pathway in human cancer: Rationale and promise

Cancer cell, 2003-10, Vol.4 (4), p.257-262

2003

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Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Science (American Association for the Advancement of Science), 2005-12, Vol.310 (5754), p.1642-1646

2005

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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Molecular cell, 2002-07, Vol.10 (1), p.151-162

2002

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Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (3), p.819-822

2007

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A motif-based profile scanning approach for genome-wide prediction of signaling pathways

Nature biotechnology, 2001-04, Vol.19 (4), p.348-353

2001

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

Nucleic acids research, 2003-07, Vol.31 (13), p.3635-3641

2003

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

The Journal of clinical investigation, 2008-09, Vol.118 (9), p.3065-3074

2008

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Tuberous Sclerosis Complex-1 and -2 Gene Products Function Together to Inhibit Mammalian Target of Rapamycin (mTOR)-Mediated Downstream Signaling

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (21), p.13571-13576

2002

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

Nature (London), 2008-03, Vol.452 (7184), p.181-186

2008

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BRD7, a Tumor Suppressor, Interacts with p85α and Regulates PI3K Activity

Molecular cell, 2014-04, Vol.54 (1), p.193-202

2014

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Large-Scale Characterization of HeLa Cell Nuclear Phosphoproteins

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.12130-12135

2004

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

The Phosphoinositide 3-Kinase Pathway

AKT/PKB Signaling: Navigating Downstream

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

The Tumor Suppressor LKB1 Kinase Directly Activates AMP-Activated Kinase and Regulates Apoptosis in Response to Energy Stress

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation

Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm

Targeting the PI3K-Akt pathway in human cancer: Rationale and promise

Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Tuberous Sclerosis Complex-1 and -2 Gene Products Function Together to Inhibit Mammalian Target of Rapamycin (mTOR)-Mediated Downstream Signaling

Pyruvate kinase M2 is a phosphotyrosine-binding protein

BRD7, a Tumor Suppressor, Interacts with p85α and Regulates PI3K Activity

Large-Scale Characterization of HeLa Cell Nuclear Phosphoproteins

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