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Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

Pharmaceutics, 2022-01, Vol.14 (1), p.217

2022

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Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo

Journal of controlled release, 2014-04, Vol.179, p.18-24

2014

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A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier

Journal of controlled release, 2010-07, Vol.145 (2), p.91-101

2010

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Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver

Pharmaceutics, 2020-05, Vol.12 (5), p.471

2020

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Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

Pharmaceutics, 2020-03, Vol.12 (3), p.278

2020

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Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.856

2007

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The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo

The Journal of pharmacology and experimental therapeutics, 2006-05, Vol.317 (2), p.514

2006

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Drug targeting to the diseased liver

Journal of controlled release, 2012-07, Vol.161 (2), p.188-197

2012

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Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells: a novel strategy to treat renal fibrosis

The Journal of pharmacology and experimental therapeutics, 2006-10, Vol.319 (1), p.8

2006

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Effects of a new bioactive lipid-based drug carrier on cultured hepatic stellate cells and liver fibrosis in bile duct-ligated rats

The Journal of pharmacology and experimental therapeutics, 2007-05, Vol.321 (2), p.536

2007

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Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine

Drug metabolism and disposition, 2007-05, Vol.35 (5), p.814

2007

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Cell-specific delivery of biologicals: problems, pitfalls and possibilities of antifibrotic compounds in the liver

Drug discovery today, 2013-12, Vol.18 (23-24), p.1237-1242

2013

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Renal-selective delivery and angiotensin-converting enzyme inhibition by subcutaneously administered captopril-lysozyme

Drug metabolism and disposition, 2005-05, Vol.33 (5), p.683

2005

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Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis

Molecular pharmaceutics, 2011-10, Vol.8 (5), p.1899-1909

2011

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Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

Pharmaceutical research, 2011-08, Vol.28 (8), p.2045-2054

2011

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PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis

Journal of controlled release, 2011-09, Vol.154 (3), p.233-240

2011

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PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice

Journal of controlled release, 2012-08, Vol.162 (1), p.84-91

2012

Volltextzugriff (PDF)

Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections

Chembiochem : a European journal of chemical biology, 2011-09, Vol.12 (13), p.2016-2020

2011

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Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers

The Journal of pharmacology and experimental therapeutics, 2008-03, Vol.324 (3), p.902

2008

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Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis

Pharmaceutical research, 2008-10, Vol.25 (10), p.2427-2439

2008

Volltextzugriff (PDF)

The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue

Biochemical pharmacology, 2003-10, Vol.66 (7), p.1307-1317

2003

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Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion

Drug metabolism and disposition, 2001-04, Vol.29 (4 Pt 1), p.361

2001

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Mannose-6-phosphate/insulin-like growth factor-II receptors may represent a target for the selective delivery of mycophenolic acid to fibrogenic cells

Pharmaceutical research, 2006-08, Vol.23 (8), p.1827-1834

2006

Volltextzugriff (PDF)

PDGF-Receptor β-Targeted Adenovirus Redirects Gene Transfer from Hepatocytes to Activated Stellate Cells

Molecular pharmaceutics, 2008-05, Vol.5 (3), p.399-406

2008

Volltextzugriff (PDF)

Rational Design of RGD-Albumin Conjugates for Targeted Delivery of the VEGF-R Kinase Inhibitor PTK787 to Angiogenic Endothelium

ChemMedChem, 2006-11, Vol.1 (11), p.1200-1203

2006

Volltextzugriff (PDF)

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Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo

A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier

Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells

The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo

Drug targeting to the diseased liver

Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells: a novel strategy to treat renal fibrosis

Effects of a new bioactive lipid-based drug carrier on cultured hepatic stellate cells and liver fibrosis in bile duct-ligated rats

Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine

Cell-specific delivery of biologicals: problems, pitfalls and possibilities of antifibrotic compounds in the liver

Renal-selective delivery and angiotensin-converting enzyme inhibition by subcutaneously administered captopril-lysozyme

Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis

PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice

Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections

Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers

Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis

The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue

Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion

Mannose-6-phosphate/insulin-like growth factor-II receptors may represent a target for the selective delivery of mycophenolic acid to fibrogenic cells

PDGF-Receptor β-Targeted Adenovirus Redirects Gene Transfer from Hepatocytes to Activated Stellate Cells

Rational Design of RGD-Albumin Conjugates for Targeted Delivery of the VEGF-R Kinase Inhibitor PTK787 to Angiogenic Endothelium

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