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Extensions to the Visual Predictive Check to facilitate model performance evaluation

Journal of pharmacokinetics and pharmacodynamics, 2008-04, Vol.35 (2), p.185-202

2008

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Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

Therapeutic drug monitoring, 2009-04, Vol.31 (2), p.187

2009

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Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

DRUG METABOLISM AND PHARMACOKINETICS, 2009-01, Vol.24 (1), p.3-15

2009

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Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar

Journal of clinical pharmacology, 2013-03, Vol.53 (3), p.256-263

2013

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Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake

British journal of clinical pharmacology, 2020-12, Vol.86 (12), p.2362-2376

2020

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Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation

British journal of clinical pharmacology, 2022-02, Vol.88 (2), p.734-741

2022

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Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview

Clinical pharmacokinetics, 2022-01, Vol.61 (1), p.1-16

2022

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Trends in pharmacological sciences (Regular ed.), 2008-04, Vol.29 (4), p.186-191

2008

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The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

Drug discovery today, 2013-09, Vol.18 (17-18), p.853-862

2013

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Model‐Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms

Journal of clinical pharmacology, 2017-05, Vol.57 (5), p.640-651

2017

Volltextzugriff (PDF)

Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.357-400

2007

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Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Journal of pharmacological and toxicological methods, 2013-05, Vol.67 (3), p.203-213

2013

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Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration

Drug metabolism and disposition, 2011-12, Vol.39 (12), p.2275

2011

Volltextzugriff (PDF)

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1367

2014

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Exploring genetic and non‐genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

British journal of clinical pharmacology, 2016-07, Vol.82 (1), p.227-237

2016

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Marginal increase of sunitinib exposure by grapefruit juice

Cancer chemotherapy and pharmacology, 2011-03, Vol.67 (3), p.695-703

2011

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Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

Journal of pharmacokinetics and pharmacodynamics, 2012-10, Vol.39 (5), p.463-477

2012

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Explaining variability in ciclosporin exposure in adult kidney transplant recipients

European journal of clinical pharmacology, 2010-06, Vol.66 (6), p.579-590

2010

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Pharmacokinetic–Pharmacodynamic Modeling of the Antihypertensive Effect of Eprosartan in Black and White Hypertensive Patients

Clinical pharmacokinetics, 2013-09, Vol.52 (9), p.793-803

2013

Volltextzugriff (PDF)

Physiologically Based Pharmacokinetic Modeling of Glycyrrhizic Acid, a Compound Subject to Presystemic Metabolism and Enterohepatic Cycling

Toxicology and applied pharmacology, 2000-02, Vol.162 (3), p.177-188

2000

Volltextzugriff (PDF)

Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

The AAPS journal, 2012-09, Vol.14 (3), p.543-553

2012

Volltextzugriff (PDF)

NT‐proBNP Qualifies as a Surrogate for Clinical End Points in Heart Failure

Clinical pharmacology and therapeutics, 2021-08, Vol.110 (2), p.498-507

2021

Volltextzugriff (PDF)

Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease

Clinical pharmacokinetics, 2020-03, Vol.59 (3), p.359-370

2020

Volltextzugriff (PDF)

CYP3A4‐mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1‐mediated effects on bilirubin glucuronidation in humans

British journal of clinical pharmacology, 2018-12, Vol.84 (12), p.2857-2866

2018

Volltextzugriff (PDF)

Exposure–response relationship of regorafenib efficacy in patients with hepatocellular carcinoma

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S149-S153

2017

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Extensions to the Visual Predictive Check to facilitate model performance evaluation

Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar

Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake

Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation

Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

Model‐Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms

Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Exploring genetic and non‐genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

Marginal increase of sunitinib exposure by grapefruit juice

Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

Explaining variability in ciclosporin exposure in adult kidney transplant recipients

Pharmacokinetic–Pharmacodynamic Modeling of the Antihypertensive Effect of Eprosartan in Black and White Hypertensive Patients

Physiologically Based Pharmacokinetic Modeling of Glycyrrhizic Acid, a Compound Subject to Presystemic Metabolism and Enterohepatic Cycling

Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

NT‐proBNP Qualifies as a Surrogate for Clinical End Points in Heart Failure

Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease

CYP3A4‐mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1‐mediated effects on bilirubin glucuronidation in humans

Exposure–response relationship of regorafenib efficacy in patients with hepatocellular carcinoma

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