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N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6454-6457

2008

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5-((1 H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1189-1192

2007

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5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2)

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5630-5633

2007

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Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1185-1188

2007

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Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2487-2491

2009

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Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6800-6803

2011

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Synthesis and SAR of highly selective MMP-13 inhibitors

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4961-4966

2005

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3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4546-4550

2009

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Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.311-316

2006

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A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer

Investigational new drugs, 2019-10, Vol.37 (5), p.1052-1060

2019

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Antimicrobial resistance surveillance of Bacteroides fragilis isolated from blood cultures, Europe, 2022 (ReSuBacfrag)

International journal of antimicrobial agents, 2024-09, Vol.64 (3), p.107241, Article 107241

2024

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Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: An interrupted time series regression analysis

Pharmacoepidemiology and drug safety, 2021-04, Vol.30 (4), p.482-491

2021

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Synthesis and structure based optimization of novel Akt inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3359-3363

2008

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Impact of EU regulatory label changes for diclofenac in people with cardiovascular disease in four countries: Interrupted time series regression analysis

British journal of clinical pharmacology, 2021-03, Vol.87 (3), p.1129-1140

2021

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Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants

Antimicrobial agents and chemotherapy, 2016-05, Vol.60 (5), p.2888-2894

2016

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Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Pharmacoepidemiology and drug safety, 2020-03, Vol.29 (3), p.296-305

2020

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Population Pharmacokinetics of Nevirapine in HIV-1-Infected Pregnant Women and Their Neonates

Antimicrobial Agents and Chemotherapy, 2011-01, Vol.55 (1), p.331-337

2011

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Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3444-3448

2006

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Population Pharmacokinetics of Tenofovir in HIV-1-Infected Pregnant Women and Their Neonates (ANRS 12109)

Clinical pharmacology and therapeutics, 2009-02, Vol.85 (2), p.182-189

2009

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In Vitro–In Vivo Correlation on Delivery of Drug Candidates to Articular Cartilage

Pharmaceutical research, 2008-07, Vol.25 (7), p.1641-1646

2008

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Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (19), p.5213-5224

2004

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Reduction by cytoprotective agents of ethanol-induced damage to the rat gastric mucosa: a correlated morphological and physiological study

Canadian journal of physiology and pharmacology, 1982-12, Vol.60 (12), p.1686-1699

1982

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Renal excretion of pseudoephedrine

Clinical pharmacology and therapeutics, 1980-11, Vol.28 (5), p.690-694

1980

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N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

5-((1 H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2)

Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition

Synthesis and SAR of highly selective MMP-13 inhibitors

3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors

A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer

Antimicrobial resistance surveillance of Bacteroides fragilis isolated from blood cultures, Europe, 2022 (ReSuBacfrag)

Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: An interrupted time series regression analysis

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

Synthesis and structure based optimization of novel Akt inhibitors

Impact of EU regulatory label changes for diclofenac in people with cardiovascular disease in four countries: Interrupted time series regression analysis

Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Population Pharmacokinetics of Nevirapine in HIV-1-Infected Pregnant Women and Their Neonates

Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists

Population Pharmacokinetics of Tenofovir in HIV-1-Infected Pregnant Women and Their Neonates (ANRS 12109)

In Vitro–In Vivo Correlation on Delivery of Drug Candidates to Articular Cartilage

Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters

Reduction by cytoprotective agents of ethanol-induced damage to the rat gastric mucosa: a correlated morphological and physiological study

Renal excretion of pseudoephedrine

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