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Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

JAMA : the journal of the American Medical Association, 2023-04, Vol.329 (13), p.1066

2023

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Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in pharmacology, 2023-03, Vol.14, p.1147495-1147495

2023

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Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Frontiers in pharmacology, 2021-04, Vol.12, p.655320

2021

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Cefazolin pharmacokinetics in premature infants

Journal of perinatology, 2019-09, Vol.39 (9), p.1213-1218

2019

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Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

Drug metabolism and disposition, 2019-08, Vol.47 (8), p.899-906

2019

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Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

Drug metabolism and disposition, 2019-02, Vol.47 (2), p.155-163

2019

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A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

PloS one, 2018-05, Vol.13 (5), p.e0197213

2018

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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.324

2016

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Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.415

2015

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Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1567

2014

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Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion

Drug metabolism and disposition, 2014-07, Vol.42 (7), p.1219

2014

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Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.509-535

2014

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Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

Frontiers in pharmacology, 2014, Vol.5, p.240-240

2014

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Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes

Molecular pharmacology, 2013-08, Vol.84 (2), p.182-189

2013

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A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.6

2012

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Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.441

2011

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Evaluation of ⁹⁹mTechnetium-Mebrofenin and ⁹⁹mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

Pharmaceutical research, 2010-09, Vol.27 (9), p.1987-1998

2010

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Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

Pharmaceutical research, 2009-08, Vol.26 (8), p.1942-1951

2009

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Relationship between drug/metabolite exposure and impairment of excretory transport function

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.386

2009

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Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Pharmaceutical research, 2008-08, Vol.25 (8), p.1851-1860

2008

Volltextzugriff (PDF)

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Drug metabolism and disposition, 2008-05, Vol.36 (5), p.911

2008

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Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.198

2008

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Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.61

2008

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Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Antimicrobial Agents and Chemotherapy, 2007-09, Vol.51 (9), p.3230-3234

2007

Volltextzugriff (PDF)

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.881

2006

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Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Cefazolin pharmacokinetics in premature infants

Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat

Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion

Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes

A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Evaluation of ⁹⁹mTechnetium-Mebrofenin and ⁹⁹mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

Relationship between drug/metabolite exposure and impairment of excretory transport function

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

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