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A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Molecular therapy, 2020-01, Vol.28 (1), p.52-63

2020

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Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

Immunity (Cambridge, Mass.), 2018-04, Vol.48 (4), p.760-772.e4

2018

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Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Frontiers in immunology, 2021-07, Vol.12, p.711621-711621

2021

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Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Blood, 2019-11, Vol.134 (19), p.1670-1682

2019

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iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

Frontiers in immunology, 2024-07, Vol.15, p.1407567

2024

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Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Blood, 2012-01, Vol.119 (2), p.619-628

2012

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TEM8 Tri-specific Killer Engager binds both tumor and tumor stroma to specifically engage natural killer cell anti-tumor activity

Journal for immunotherapy of cancer, 2022-09, Vol.10 (9), p.e004725

2022

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iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

Journal for immunotherapy of cancer, 2023-12, Vol.11 (12), p.e007280

2023

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Isolation and characterization of canine natural killer cells

Veterinary immunology and immunopathology, 2013-09, Vol.155 (3), p.211-217

2013

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Dinaciclib enhances natural killer cell cytotoxicity against acute myelogenous leukemia

Blood advances, 2019-08, Vol.3 (16), p.2448-2452

2019

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Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists

International immunology, 2006-07, Vol.18 (7), p.1115-1126

2006

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Setting traps for NKG2A gives NK cell immunotherapy a fighting chance

The Journal of clinical investigation, 2019-05, Vol.129 (5), p.1839-1841

2019

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NK Cells from Human Cytomegalovirus-Seropositive Individuals Have a Distinct Metabolic Profile That Correlates with Elevated mTOR Signaling

The Journal of immunology (1950), 2023-08, Vol.211 (4), p.539-550

2023

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IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

Clinical cancer research, 2016-07, Vol.22 (14), p.3440-3450

2016

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Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells

Gynecologic oncology, 2019-04, Vol.153 (1), p.149-157

2019

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Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

JCI insight, 2018-02, Vol.3 (3)

2018

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GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity

Cancer research (Chicago, Ill.), 2017-10, Vol.77 (20), p.5664-5675

2017

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Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease

The Journal of clinical investigation, 2020-09, Vol.130 (9), p.4652-4662

2020

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GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Blood, 2015-09, Vol.126 (13), p.1621-1628

2015

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Lineage relationships of human interleukin-22–producing CD56+ RORγt+ innate lymphoid cells and conventional natural killer cells

Blood, 2013-03, Vol.121 (12), p.2234-2243

2013

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Reverse Translation Identifies the Synergistic Role of Immune Checkpoint Blockade and IL15 to Enhance Immunotherapy of Ovarian Cancer

Cancer immunology research, 2023-05, Vol.11 (5), p.674-686

2023

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Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models

Cytokine (Philadelphia, Pa.), 2018-07, Vol.107, p.105-112

2018

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Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice

Molecular therapy, 2018-06, Vol.26 (6), p.1423-1434

2018

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A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

TEM8 Tri-specific Killer Engager binds both tumor and tumor stroma to specifically engage natural killer cell anti-tumor activity

iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting

Isolation and characterization of canine natural killer cells

Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia

Dinaciclib enhances natural killer cell cytotoxicity against acute myelogenous leukemia

Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists

Setting traps for NKG2A gives NK cell immunotherapy a fighting chance

NK Cells from Human Cytomegalovirus-Seropositive Individuals Have a Distinct Metabolic Profile That Correlates with Elevated mTOR Signaling

IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity

Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Lineage relationships of human interleukin-22–producing CD56+ RORγt+ innate lymphoid cells and conventional natural killer cells

Reverse Translation Identifies the Synergistic Role of Immune Checkpoint Blockade and IL15 to Enhance Immunotherapy of Ovarian Cancer

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models

Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice

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