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HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements

Biochemistry (Easton), 2012-04, Vol.51 (13), p.2819-2828

2012

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Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV‑1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme

Biochemistry (Easton), 2016-04, Vol.55 (16), p.2390-2400

2016

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Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease

The Journal of biological chemistry, 2008-05, Vol.283 (19), p.13459-13470

2008

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Terminal Interface Conformations Modulate Dimer Stability Prior to Amino Terminal Autoprocessing of HIV-1 Protease

Biochemistry (Easton), 2012-02, Vol.51 (5), p.1041-1050

2012

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Mutations Proximal to Sites of Autoproteolysis and the α‑Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV‑1 Protease

Biochemistry (Easton), 2015-09, Vol.54 (35), p.5414-5424

2015

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Extreme Multidrug Resistant HIV‑1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1′-Pyrrolidinone or P2-Tris-tetrahydrofuran

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.4017-4027

2013

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Mechanism of Dissociative Inhibition of HIV Protease and Its Autoprocessing from a Precursor

Journal of molecular biology, 2012-09, Vol.422 (2), p.230-244

2012

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Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV‐1 protease: Relevance to drug resistance

Protein science, 2010-11, Vol.19 (11), p.2055-2072

2010

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Revealing the dimer dissociation and existence of a folded monomer of the mature HIV‐2 protease

Protein science, 2009-12, Vol.18 (12), p.2442-2453

2009

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Interactions of different inhibitors with active‐site aspartyl residues of HIV‐1 protease and possible relevance to pepsin

Proteins, structure, function, and bioinformatics, 2009-05, Vol.75 (3), p.556-568

2009

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Enhanced Stability of Monomer Fold Correlates with Extreme Drug Resistance of HIV‑1 Protease

Biochemistry (Easton), 2013-10, Vol.52 (43), p.7678-7688

2013

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The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts

Biochemistry (Easton), 2011-05, Vol.50 (21), p.4786-4795

2011

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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA

The EMBO journal, 2002-12, Vol.21 (23), p.6614-6624

2002

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Modulation of Human Immunodeficiency Virus Type 1 Protease Autoprocessing by Charge Properties of Surface Residue 69

Journal of Virology, 2009-08, Vol.83 (15), p.7789-7793

2009

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Efficiency and Accuracy of SOS-induced DNA Polymerases Replicating Benzo[a]pyrene-7,8-diol 9,10-Epoxide A and G Adducts

The Journal of biological chemistry, 2002-02, Vol.277 (7), p.5265-5274

2002

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Nuclear Magnetic Resonance Solution Structure of an N 2‑Guanine DNA Adduct Derived from the Potent Tumorigen Dibenzo[a,l]pyrene: Intercalation from the Minor Groove with Ruptured Watson–Crick Base Pairing

Biochemistry (Easton), 2012-12, Vol.51 (48), p.9751-9762

2012

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Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNA

The Journal of biological chemistry, 2003-05, Vol.278 (18), p.16280-16288

2003

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Preferential Misincorporation of Purine Nucleotides by Human DNA Polymerase η Opposite Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Deoxyguanosine Adducts

The Journal of biological chemistry, 2002-04, Vol.277 (14), p.11765-11771

2002

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Human Topoisomerase I Inhibition: Docking Camptothecin and Derivatives into a Structure-Based Active Site Model

Biochemistry (Easton), 2002-02, Vol.41 (5), p.1428-1435

2002

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Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota

Nucleic acids research, 2002-12, Vol.30 (23), p.5284-5292

2002

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Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine

Nucleic acids research, 2004-01, Vol.32 (1), p.397

2004

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Individual Nucleotide Bases, Not Base Pairs, Are Critical for Triggering Site-specific DNA Cleavage by Vaccinia Topoisomerase

The Journal of biological chemistry, 2004-09, Vol.279 (38), p.39718-39726

2004

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Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A

The Journal of biological chemistry, 2006-03, Vol.281 (9), p.6000-6009

2006

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Intercalating Polycyclic Aromatic Hydrocarbon−DNA Adducts Poison DNA Religation by Vaccinia Topoisomerase and Act as Roadblocks to Digestion by Exonuclease III

Biochemistry (Easton), 2006-06, Vol.45 (24), p.7644-7653

2006

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Different Effects on Human Topoisomerase I by Minor Groove and Intercalated Deoxyguanosine Adducts Derived from Two Polycyclic Aromatic Hydrocarbon Diol Epoxides at or Near a Normal Cleavage Site

The Journal of biological chemistry, 2002-04, Vol.277 (16), p.13666-13672

2002

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HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements

Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV‑1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme

Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease

Terminal Interface Conformations Modulate Dimer Stability Prior to Amino Terminal Autoprocessing of HIV-1 Protease

Mutations Proximal to Sites of Autoproteolysis and the α‑Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV‑1 Protease

Extreme Multidrug Resistant HIV‑1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1′-Pyrrolidinone or P2-Tris-tetrahydrofuran

Mechanism of Dissociative Inhibition of HIV Protease and Its Autoprocessing from a Precursor

Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV‐1 protease: Relevance to drug resistance

Revealing the dimer dissociation and existence of a folded monomer of the mature HIV‐2 protease

Interactions of different inhibitors with active‐site aspartyl residues of HIV‐1 protease and possible relevance to pepsin

Enhanced Stability of Monomer Fold Correlates with Extreme Drug Resistance of HIV‑1 Protease

The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA

Modulation of Human Immunodeficiency Virus Type 1 Protease Autoprocessing by Charge Properties of Surface Residue 69

Efficiency and Accuracy of SOS-induced DNA Polymerases Replicating Benzo[a]pyrene-7,8-diol 9,10-Epoxide A and G Adducts

Nuclear Magnetic Resonance Solution Structure of an N 2‑Guanine DNA Adduct Derived from the Potent Tumorigen Dibenzo[a,l]pyrene: Intercalation from the Minor Groove with Ruptured Watson–Crick Base Pairing

Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNA

Preferential Misincorporation of Purine Nucleotides by Human DNA Polymerase η Opposite Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Deoxyguanosine Adducts

Human Topoisomerase I Inhibition: Docking Camptothecin and Derivatives into a Structure-Based Active Site Model

Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine

Individual Nucleotide Bases, Not Base Pairs, Are Critical for Triggering Site-specific DNA Cleavage by Vaccinia Topoisomerase

Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A

Intercalating Polycyclic Aromatic Hydrocarbon−DNA Adducts Poison DNA Religation by Vaccinia Topoisomerase and Act as Roadblocks to Digestion by Exonuclease III

Different Effects on Human Topoisomerase I by Minor Groove and Intercalated Deoxyguanosine Adducts Derived from Two Polycyclic Aromatic Hydrocarbon Diol Epoxides at or Near a Normal Cleavage Site

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