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PI3K inhibitors in inflammation, autoimmunity and cancer

Current opinion in pharmacology, 2015-08, Vol.23, p.82-91

2015

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Histamine-secreting microbes are increased in the gut of adult asthma patients

Journal of allergy and clinical immunology, 2016-11, Vol.138 (5), p.1491-1494.e7

2016

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IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

EMBO molecular medicine, 2016-09, Vol.8 (9), p.1099-1112

2016

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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

Nature communications, 2019-12, Vol.10 (1), p.5711-14, Article 5711

2019

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Airway host-microbiome interactions in chronic obstructive pulmonary disease

Respiratory research, 2019-06, Vol.20 (1), p.113-113, Article 113

2019

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Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

American journal of respiratory and critical care medicine, 2016-10, Vol.194 (8), p.961-973

2016

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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Nature communications, 2018-08, Vol.9 (1), p.3174-16, Article 3174

2018

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The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

International journal of chronic obstructive pulmonary disease, 2018-01, Vol.13, p.771-780

2018

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Functions of T cells in asthma: more than just T(H)2 cells

Nature reviews. Immunology, 2010-12, Vol.10 (12), p.838

2010

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Alkyl Passivation and Amphiphilic Polymer Coating of Silicon Nanocrystals for Diagnostic Imaging

Small (Weinheim an der Bergstrasse, Germany), 2010-09, Vol.6 (18), p.2026-2034

2010

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Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort

International journal of chronic obstructive pulmonary disease, 2021-01, Vol.16, p.225-244

2021

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Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study

International journal of chronic obstructive pulmonary disease, 2021-01, Vol.16, p.1637-1646

2021

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Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases

Annals of the New York Academy of Sciences, 2013-03, Vol.1280 (1), p.35-39

2013

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Copper Selenide Nanocrystals for Photothermal Therapy

Nano letters, 2011-06, Vol.11 (6), p.2560-2566

2011

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Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK

International journal of chronic obstructive pulmonary disease, 2017, Vol.12, p.1507-1518

2017

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Nature medicine, 2007-05, Vol.13 (5), p.552-559

2007

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Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

Human reproduction (Oxford), 2016-08, Vol.31 (8), p.1738-1748

2016

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Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

Blood, 2005-01, Vol.105 (2), p.489-495

2005

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Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals

Clinical therapeutics, 2019-06, Vol.41 (6), p.1214-1220

2019

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Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

The Journal of cell biology, 2017-04, Vol.216 (4), p.1123-1141

2017

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Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD

Pulmonary pharmacology & therapeutics, 2017-10, Vol.46, p.69-77

2017

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Altered fatty acid metabolism and reduced stearoyl‐coenzyme a desaturase activity in asthma

Allergy (Copenhagen), 2017-11, Vol.72 (11), p.1744-1752

2017

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Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

The Journal of pharmacology and experimental therapeutics, 2019-06, Vol.369 (3), p.337-344

2019

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A novel cell-processing method ‘AgarCytos’ in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Human reproduction (Oxford), 2013-10, Vol.28 (10), p.2608-2620

2013

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The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport

American journal of respiratory cell and molecular biology, 2024-09, Vol.71 (3), p.282-293

2024

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PI3K inhibitors in inflammation, autoimmunity and cancer

Histamine-secreting microbes are increased in the gut of adult asthma patients

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

Airway host-microbiome interactions in chronic obstructive pulmonary disease

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

Functions of T cells in asthma: more than just T(H)2 cells

Alkyl Passivation and Amphiphilic Polymer Coating of Silicon Nanocrystals for Diagnostic Imaging

Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort

Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases

Copper Selenide Nanocrystals for Photothermal Therapy

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD

Altered fatty acid metabolism and reduced stearoyl‐coenzyme a desaturase activity in asthma

Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

A novel cell-processing method ‘AgarCytos’ in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport

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