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Randomised clinical trial: arbaclofen placarbil in gastro‐oesophageal reflux disease – insights into study design for transient lower sphincter relaxation inhibitors

Alimentary pharmacology & therapeutics, 2013-07, Vol.38 (2), p.107-117

2013

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Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

Clinical pharmacokinetics, 1999-02, Vol.36 (2), p.127-143

CUNDY, K. C

1999

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Anti-Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-Infected Patients

The Journal of infectious diseases, 1997-08, Vol.176 (2), p.406-413

1997

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Antioxidant Activity of Carnosine, Homocarnosine, and Anserine Present in Muscle and Brain

Proceedings of the National Academy of Sciences - PNAS, 1988-05, Vol.85 (9), p.3175-3179

1988

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Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

Antimicrobial Agents and Chemotherapy, 1995-06, Vol.39 (6), p.1247-1252

1995

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Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

Antimicrobial Agents and Chemotherapy, 1998-09, Vol.42 (9), p.2380-2384

1998

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Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

Antimicrobial Agents and Chemotherapy, 1995-11, Vol.39 (11), p.2401-2405

1995

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Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

Antiviral research, 1996-03, Vol.29 (2), p.153-161

1996

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1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Antimicrobial Agents and Chemotherapy, 1994-10, Vol.38 (10), p.2387-2391

1994

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The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil

International journal of clinical pharmacology and therapeutics, 2010-02, Vol.48 (2), p.120-128

2010

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Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques

AIDS research and human retroviruses, 1998-06, Vol.14 (9), p.761-773

1998

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[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

Methods in Enzymology, 1990, Vol.186, p.521-530

1990

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Clinical Pharmacokinetics of 1-[((S)-2-Hydroxy-2-Oxo-1,4,2-Dioxaphosphorinan-5-yl)methyl]cytosine in Human Immunodeficiency Virus-Infected Patients

Antimicrobial Agents and Chemotherapy, 1999-02, Vol.43 (2), p.271-277

1999

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Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis

Clinical pharmacology and therapeutics, 1999, Vol.65 (1), p.21-28

1999

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Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1898-1906

2005

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Aryl ester prodrugs of cyclic HPMPC. I : Physicochemical characterization and in vitro biological stability

Pharmaceutical research, 1999-11, Vol.16 (11), p.1687-1693

1999

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Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis

Journal of ocular pharmacology and therapeutics, 1998-04, Vol.14 (2), p.147-151

1998

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Efficacy of Gabapentin Enacarbil vs Placebo in Patients with Postherpetic Neuralgia and a Pharmacokinetic Comparison with Oral Gabapentin

Pain medicine (Malden, Mass.), 2011-07, Vol.12 (7), p.1098-1108

2011

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XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.315-323

2004

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A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome

Clinical neuropharmacology, 2012-07, Vol.35 (4), p.165-173

2012

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A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers

International journal of clinical pharmacology and therapeutics, 2011-02, Vol.49 (2), p.109-115

2011

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High-performance liquid chromatographic determination of GS4071, a potent inhibitor of influenza neuraminidase, in plasma by precolumn fluorescence derivatization with naphthalenedialdehyde

Journal of chromatography. B, Biomedical sciences and applications, 1998-09, Vol.716 (1), p.267-273

1998

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A novel oligodeoxynucleotide inhibitor of thrombin. I: In vitro metabolic stability in plasma and serum

Pharmaceutical research, 1995-12, Vol.12 (12), p.1937-1942

1995

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Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits

Current eye research, 1996-05, Vol.15 (5), p.569-576

1996

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Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in vivo oxidative DNA damage

Basic life sciences, 1988, Vol.49, p.479

1988

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Randomised clinical trial: arbaclofen placarbil in gastro‐oesophageal reflux disease – insights into study design for transient lower sphincter relaxation inhibitors

Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

Anti-Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-Infected Patients

Antioxidant Activity of Carnosine, Homocarnosine, and Anserine Present in Muscle and Brain

Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil

Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques

[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

Clinical Pharmacokinetics of 1-[((S)-2-Hydroxy-2-Oxo-1,4,2-Dioxaphosphorinan-5-yl)methyl]cytosine in Human Immunodeficiency Virus-Infected Patients

Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysis

Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

Aryl ester prodrugs of cyclic HPMPC. I : Physicochemical characterization and in vitro biological stability

Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis

Efficacy of Gabapentin Enacarbil vs Placebo in Patients with Postherpetic Neuralgia and a Pharmacokinetic Comparison with Oral Gabapentin

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters

A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome

A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers

High-performance liquid chromatographic determination of GS4071, a potent inhibitor of influenza neuraminidase, in plasma by precolumn fluorescence derivatization with naphthalenedialdehyde

A novel oligodeoxynucleotide inhibitor of thrombin. I: In vitro metabolic stability in plasma and serum

Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits

Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in vivo oxidative DNA damage

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