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Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin

Cancer cell, 2023-09, Vol.41 (9), p.1567-1585.e7

2023

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Molecular cell, 2013-01, Vol.49 (1), p.172-185

2013

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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Nature medicine, 2015-05, Vol.21 (5), p.457-466

2015

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PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

Cell, 2013-10, Vol.155 (2), p.397-409

2013

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Nature cell biology, 2012-12, Vol.14 (12), p.1295-1304

2012

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Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Nature (London), 2021-01, Vol.589 (7841), p.270-275

2021

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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Nature cell biology, 2016-05, Vol.18 (5), p.572-578

2016

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Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation

Molecular cell, 2013-10, Vol.52 (2), p.161-172

2013

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Cancer discovery, 2015-11, Vol.5 (11), p.1194-1209

2015

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Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm

Oncogene, 2015-09, Vol.34 (36), p.4702-4712

2015

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Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Science (American Association for the Advancement of Science), 2005-12, Vol.310 (5754), p.1642-1646

2005

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Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer

Nature communications, 2022-08, Vol.13 (1), p.4633-4633, Article 4633

2022

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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Cell, 2017-12, Vol.171 (7), p.1545-1558.e18

2017

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Stromal cells protect against acute tubular injury via an endocrine effect

Journal of the American Society of Nephrology, 2007-09, Vol.18 (9), p.2486-2496

2007

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Biomarkers of inflammation and repair in kidney disease progression

The Journal of clinical investigation, 2021-02, Vol.131 (3), p.1-10

2021

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Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Breast cancer research : BCR, 2019-07, Vol.21 (1), p.78-78, Article 78

2019

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Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer

Annals of oncology, 2017-03, Vol.28 (3), p.512-518

2017

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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Nature (London), 2016-08, Vol.536 (7617), p.479-483

2016

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Age-induced accumulation of methylmalonic acid promotes tumour progression

Nature (London), 2020-09, Vol.585 (7824), p.283-287

2020

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Idelalisib — A PI3Kδ Inhibitor for B-Cell Cancers

The New England journal of medicine, 2014-03, Vol.370 (11), p.1061-1062

2014

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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Science (American Association for the Advancement of Science), 2015-12, Vol.350 (6266), p.1391-1396

2015

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Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer

Breast cancer research : BCR, 2020-11, Vol.22 (1), p.120-120, Article 120

2020

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Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

Cancer cell, 2009-08, Vol.16 (2), p.115-125

2009

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Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm

Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Stromal cells protect against acute tubular injury via an endocrine effect

Biomarkers of inflammation and repair in kidney disease progression

Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Age-induced accumulation of methylmalonic acid promotes tumour progression

Idelalisib — A PI3Kδ Inhibitor for B-Cell Cancers

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

Chromosomal instability drives metastasis through a cytosolic DNA response

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