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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.905-909

2005

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Protein Stabilization and Delivery: A Case Study of Invasion Plasmid Antigen D Adsorbed on Porous Silica

Langmuir, 2020-12, Vol.36 (47), p.14276-14287

2020

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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Pharmaceutical research, 2017-02, Vol.34 (2), p.333-351

2017

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Catalytic oxidation of alkanethiols and dialkyldisulfides to alkanesulfonic acids by H2O2/CH3ReO3 examined by electrospray ionization mass spectrometry

Journal of mass spectrometry., 2014-03, Vol.49 (3), p.241-247

2014

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Application of Screening Methods, Shape Signatures and Engineered Biosensors in Early Drug Discovery Process

Pharmaceutical research, 2009-10, Vol.26 (10), p.2247-2258

2009

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Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1488-1491

2009

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Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1775-1779

2006

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Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1780-1783

2006

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Synthesis and biological evaluation of unnatural canthine alkaloids

Tetrahedron letters, 2005-04, Vol.46 (16), p.2779-2782

2005

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Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.351-355

2004

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Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1492-1495

2009

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N-Heterocyclic derived M 1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (4), p.1334-1337

2010

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Pyridine containing M 1 positive allosteric modulators with reduced plasma protein binding

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.657-661

2010

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Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.25

2002

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The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.2027-2030

2002

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Design and Construction of A Cerenkov Counter for In Situ Monitoring of Sr-90 in Groundwater

Journal of radioanalytical and nuclear chemistry, 2008-07, Vol.277 (1)

2008

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Non-Peptide α vβ 3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-Amino acids as aspartic acid replacements

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.31-34

2002

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Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors

Bioorganic & medicinal chemistry letters, 1999-03, Vol.9 (6), p.863-868

1999

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Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.3027-3033

1992

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High current density field emission from transition metal carbides

Applied surface science, 1993-04, Vol.67 (1), p.29-35

1993

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4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3822-3831

1992

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Economical electrophoresis with a controlled-current power supply

Journal of chemical education, 1990-08, Vol.67 (8), p.703

1990

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Synthesis of novel 3-(alkylthio)-2-halopyridines and related derivatives

Journal of organic chemistry, 1979-08, Vol.44 (17), p.3080-3082

1979

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Piperazinylquinoxalines with central serotoninmimetic activity

Journal of medicinal chemistry, 1981-01, Vol.24 (1), p.93-101

1981

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Protein Stabilization and Delivery: A Case Study of Invasion Plasmid Antigen D Adsorbed on Porous Silica

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Catalytic oxidation of alkanethiols and dialkyldisulfides to alkanesulfonic acids by H2O2/CH3ReO3 examined by electrospray ionization mass spectrometry

Application of Screening Methods, Shape Signatures and Engineered Biosensors in Early Drug Discovery Process

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Synthesis and biological evaluation of unnatural canthine alkaloids

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

N-Heterocyclic derived M 1 positive allosteric modulators

Pyridine containing M 1 positive allosteric modulators with reduced plasma protein binding

Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases

Design and Construction of A Cerenkov Counter for In Situ Monitoring of Sr-90 in Groundwater

Non-Peptide α vβ 3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-Amino acids as aspartic acid replacements

Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

High current density field emission from transition metal carbides

4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Economical electrophoresis with a controlled-current power supply

Synthesis of novel 3-(alkylthio)-2-halopyridines and related derivatives

Piperazinylquinoxalines with central serotoninmimetic activity

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