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Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors

The Journal of pharmacology and experimental therapeutics, 2022-02, Vol.380 (2), p.114

2022

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Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Science (American Association for the Advancement of Science), 2021-02, Vol.371 (6532)

2021

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Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

The Journal of pharmacology and experimental therapeutics, 2020-05, Vol.373 (2), p.261

2020

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Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes

Journal of pharmacy & pharmaceutical sciences, 2019, Vol.22 (1), p.567

2019

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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.865-889

2018

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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.324

2016

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Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.415

2015

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Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1964

2014

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Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion

Drug metabolism and disposition, 2014-07, Vol.42 (7), p.1219

2014

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Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion of Anionic Probe Substrates

Toxicological sciences, 2014-05, Vol.139 (1), p.99-107

2014

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An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR– Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown

Molecular pharmaceutics, 2014-03, Vol.11 (3), p.766-775

2014

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.737

2013

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.727

2013

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Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue

Drug metabolism and disposition, 2013-11, Vol.41 (11), p.1949

2013

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Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites

Drug metabolism and disposition, 2013-06, Vol.41 (6), p.1179

2013

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Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes

Drug metabolism and disposition, 2013-01, Vol.41 (1), p.188

2013

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Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

Toxicology and applied pharmacology, 2012-05, Vol.261 (1), p.1-9

2012

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Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes

Toxicological sciences, 2011-04, Vol.120 (2), p.371-380

2011

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Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.441

2011

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In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats

Drug metabolism and disposition, 2010-10, Vol.38 (10), p.1848

2010

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Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Pharmaceutical research, 2010-09, Vol.27 (9), p.1987

2010

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Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes

The Journal of pharmacology and experimental therapeutics, 2010-08, Vol.334 (2), p.410

2010

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Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

Molecular pharmaceutics, 2010-04, Vol.7 (2), p.491-500

2010

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Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

Toxicology in vitro, 2010-02, Vol.24 (1), p.297-309

2010

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Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.26

2010

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Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation

Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion

Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion of Anionic Probe Substrates

An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR– Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue

Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites

Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats

Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes

Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation

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