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Glutamate receptor agonist injections into the dorsal striatum cause contralateral turning in the rat: involvement of kainate and AMPA receptors

European journal of pharmacology, 1996-04, Vol.301 (1), p.7-17

1996

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Mechanisms of ketamine and its metabolites as antidepressants

Biochemical pharmacology, 2022-03, Vol.197, p.114892-114892, Article 114892

2022

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Repurposing Metformin for Vascular Disease

Current medicinal chemistry, 2023-01, Vol.30 (35), p.3955-3978

2023

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A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer

Journal of controlled release, 2017-12, Vol.267, p.191-202

2017

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The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA)

Canadian journal of physiology and pharmacology, 2015-10, Vol.93 (10), p.843-854

2015

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Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3

Life sciences (1973), 2022-06, Vol.299, p.120528-120528, Article 120528

2022

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Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2718-2733

2016

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Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease

The Journal of pharmacology and experimental therapeutics, 2020-08, Vol.374 (2), p.342-353

2020

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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8468-8484

2010

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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

The Journal of pharmacology and experimental therapeutics, 2017-01, Vol.360 (1), p.117-128

2017

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Intracranial Applications of Magnetic Resonance-guided Focused Ultrasound

Neurotherapeutics, 2014-07, Vol.11 (3), p.593-605

2014

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Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

Neuropharmacology, 2017-04, Vol.116, p.59-70

2017

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A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction

The Journal of pharmacology and experimental therapeutics, 2019-04, Vol.369 (1), p.9-25

2019

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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

The Journal of pharmacology and experimental therapeutics, 2017-11, Vol.363 (2), p.240-252

2017

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Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

Journal of controlled release, 2017-03, Vol.249, p.173-182

2017

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Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107515, Article 107515

2024

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Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2568-2580

2013

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Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters

Neuropharmacology, 2023-03, Vol.225, p.109403-109403, Article 109403

2023

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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.804-810

2013

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Safe and Sustained Vaginal Delivery of Pyrimidinedione HIV-1 Inhibitors from Polyurethane Intravaginal Rings

Antimicrobial Agents and Chemotherapy, 2012-03, Vol.56 (3), p.1291-1299

2012

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The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease

International immunopharmacology, 2021-11, Vol.100, p.108069-108069, Article 108069

2021

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A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder

The Journal of pharmacology and experimental therapeutics, 2016-02, Vol.356 (2), p.493-502

2016

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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7808-7816

2009

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FIP/AAPS Joint Workshop Report: Dissolution/In Vitro Release Testing of Novel/Special Dosage Forms

AAPS PharmSciTech, 2011-06, Vol.12 (2), p.782-794

2011

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Glutamate receptor agonist injections into the dorsal striatum cause contralateral turning in the rat: involvement of kainate and AMPA receptors

Mechanisms of ketamine and its metabolites as antidepressants

Repurposing Metformin for Vascular Disease

A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer

The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA)

Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3

Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Intracranial Applications of Magnetic Resonance-guided Focused Ultrasound

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction

Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

Safe and Sustained Vaginal Delivery of Pyrimidinedione HIV-1 Inhibitors from Polyurethane Intravaginal Rings

The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease

A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder

Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer’s Disease

Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

FIP/AAPS Joint Workshop Report: Dissolution/In Vitro Release Testing of Novel/Special Dosage Forms

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