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Targeting Tyrosine Phosphatases: Time to End the Stigma

Trends in pharmacological sciences (Regular ed.), 2017-06, Vol.38 (6), p.524-540

2017

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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders

Nature reviews. Drug discovery, 2023-04, Vol.22 (4), p.273-294

2023

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PTPN22: the archetypal non-HLA autoimmunity gene

Nature reviews. Rheumatology, 2014-10, Vol.10 (10), p.602-611

2014

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The Contribution of PTPN22 to Rheumatic Disease

Arthritis & rheumatology (Hoboken, N.J.), 2019-04, Vol.71 (4), p.486-495

2019

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PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Nature communications, 2017-10, Vol.8 (1), p.1060-14, Article 1060

2017

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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

Nature chemical biology, 2017-03, Vol.13 (6), p.624-632

2017

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Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

Cell reports (Cambridge), 2021-08, Vol.36 (6), p.109525-109525, Article 109525

2021

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T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity

Journal of allergy and clinical immunology, 2016-09, Vol.138 (3), p.839-851.e8

2016

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Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

Science translational medicine, 2015-05, Vol.7 (288), p.288ra76

2015

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Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4790-4795

2008

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Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast‐like Synoviocytes: A Novel Role of SH2 Domain–Containing Phosphatase 2 as a Modulator of Invasion and Survival

Arthritis & rheumatology (Hoboken, N.J.), 2013-05, Vol.65 (5), p.1171-1180

2013

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Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

The Journal of biological chemistry, 2010-08, Vol.285 (34), p.26506-26518

2010

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PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis

JCI insight, 2020-10, Vol.5 (20)

2020

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Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

Immunology, 2012-09, Vol.137 (1), p.1-19

2012

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Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells

PloS one, 2014-02, Vol.9 (2), p.e86677-e86677

2014

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High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (35), p.13972-13977

2012

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Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy

The Journal of pathology, 2015-12, Vol.237 (4), p.482-494

2015

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RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4923-4936

2020

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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

PloS one, 2015-06, Vol.10 (6), p.e0129264

2015

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Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

JCI insight, 2016-05, Vol.1 (7)

2016

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A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

The Journal of biological chemistry, 2024-06, Vol.300 (6), p.107393, Article 107393

2024

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The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy

Journal of cellular physiology, 2021-09, Vol.236 (9), p.6630-6642

2021

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PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes

Annals of the rheumatic diseases, 2019-05, Vol.78 (5), p.600-609

2019

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PTPN22 alters the development of regulatory T cells in the thymus

The Journal of immunology (1950), 2012-06, Vol.188 (11), p.5267-5275

2012

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1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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Targeting Tyrosine Phosphatases: Time to End the Stigma

Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders

PTPN22: the archetypal non-HLA autoimmunity gene

The Contribution of PTPN22 to Rheumatic Disease

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast‐like Synoviocytes: A Novel Role of SH2 Domain–Containing Phosphatase 2 as a Modulator of Invasion and Survival

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy

RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy

PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes

PTPN22 alters the development of regulatory T cells in the thymus

1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy

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