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Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

Advanced drug delivery reviews, 2016-06, Vol.101, p.34-41

Lipinski, Christopher A.

2016

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Advanced drug delivery reviews, 2012-12, Vol.64, p.4-17

2012

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Lead- and drug-like compounds: the rule-of-five revolution

Drug discovery today. Technologies, 2004-12, Vol.1 (4), p.337-341

Lipinski, Christopher A.

2004

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Inhibition of Sirtuin Deacylase Activity by Peroxynitrite

Biochemistry (Easton), 2024-10, Vol.63 (19), p.2463-2476

2024

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Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy

PloS one, 2012-11, Vol.7 (11), p.e49006

2012

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SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates

Bioinformatics, 2020-06, Vol.36 (11), p.3447-3456

2020

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Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types

American journal of physiology. Regulatory, integrative and comparative physiology, 2024-06, Vol.326 (6), p.R515-R527

2024

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SP2: Rapid and Automatable Contaminant Removal from Peptide Samples for Proteomic Analyses

Journal of proteome research, 2019-04, Vol.18 (4), p.1644-1656

2019

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Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs

Frontiers in pharmacology, 2022-08, Vol.13, p.917968-917968

2022

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Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans

eLife, 2018-06, Vol.7

2018

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Drug-like properties and the causes of poor solubility and poor permeability

Journal of pharmacological and toxicological methods, 2000-07, Vol.44 (1), p.235-249

Lipinski, Christopher A.

2000

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Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies

PloS one, 2014-09, Vol.9 (9), p.e106294-e106294

2014

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A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations

PLoS pathogens, 2023-08, Vol.19 (8), p.e1011592

2023

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HDL induces the expression of the M2 macrophage markers arginase 1 and Fizz-1 in a STAT6-dependent process

PloS one, 2013-08, Vol.8 (8), p.e74676-e74676

2013

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Exercise training improves exercise capacity and quality of life in patients with inoperable or residual chronic thromboembolic pulmonary hypertension

PloS one, 2012-07, Vol.7 (7), p.e41603-e41603

2012

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Advanced drug delivery reviews, 2001-03, Vol.46 (1), p.3-26

2001

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Molecular docking‐guided synthesis of NSAID–glucosamine bioconjugates and their evaluation as COX‐1/COX‐2 inhibitors with potentially reduced gastric toxicity

Chemical biology & drug design, 2021-07, Vol.98 (1), p.102-113

2021

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Intravenous N-acetylcysteine for prevention of contrast-induced nephropathy: a meta-analysis of randomized, controlled trials

PloS one, 2013-01, Vol.8 (1), p.e55124

2013

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Impact of Frequent Administration of Bacteriophage on Therapeutic Efficacy in an A. baumannii Mouse Wound Infection Model

Frontiers in microbiology, 2020-03, Vol.11, p.414-414

2020

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Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths

ACS chemical biology, 2018-04, Vol.13 (4), p.1048-1056

2018

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Female sex is associated with worse prognosis in patients with hypertrophic cardiomyopathy in China

PloS one, 2014-07, Vol.9 (7), p.e102969-e102969

2014

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The rule of five should not impede anti-parasitic drug development

International journal for parasitology -- drugs and drug resistance, 2017-08, Vol.7 (2), p.248-249

2017

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Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome

International journal of molecular sciences, 2023-12, Vol.25 (1), p.531

2023

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Efficacy of standard and intensive statin treatment for the secondary prevention of cardiovascular and cerebrovascular events in diabetes patients: a meta-analysis

PloS one, 2014-11, Vol.9 (11), p.e111247-e111247

2014

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Home-based aerobic interval training improves peak oxygen uptake equal to residential cardiac rehabilitation: a randomized, controlled trial

PloS one, 2012-07, Vol.7 (7), p.e41199-e41199

2012

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Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Lead- and drug-like compounds: the rule-of-five revolution

Inhibition of Sirtuin Deacylase Activity by Peroxynitrite

Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy

SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types

SP2: Rapid and Automatable Contaminant Removal from Peptide Samples for Proteomic Analyses

Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs

Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans

Drug-like properties and the causes of poor solubility and poor permeability

Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations

HDL induces the expression of the M2 macrophage markers arginase 1 and Fizz-1 in a STAT6-dependent process

Exercise training improves exercise capacity and quality of life in patients with inoperable or residual chronic thromboembolic pulmonary hypertension

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Molecular docking‐guided synthesis of NSAID–glucosamine bioconjugates and their evaluation as COX‐1/COX‐2 inhibitors with potentially reduced gastric toxicity

Intravenous N-acetylcysteine for prevention of contrast-induced nephropathy: a meta-analysis of randomized, controlled trials

Impact of Frequent Administration of Bacteriophage on Therapeutic Efficacy in an A. baumannii Mouse Wound Infection Model

Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths

Female sex is associated with worse prognosis in patients with hypertrophic cardiomyopathy in China

The rule of five should not impede anti-parasitic drug development

Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome

Efficacy of standard and intensive statin treatment for the secondary prevention of cardiovascular and cerebrovascular events in diabetes patients: a meta-analysis

Home-based aerobic interval training improves peak oxygen uptake equal to residential cardiac rehabilitation: a randomized, controlled trial

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