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Fatty Acids and Insulin Secretion: From FFAR and Near?

Diabetes (New York, N.Y.), 2018-10, Vol.67 (10), p.1932-1934

Poitout, Vincent

2018

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Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges

Nature reviews. Endocrinology, 2021-03, Vol.17 (3), p.162

2021

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The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

Trends in endocrinology and metabolism, 2013-08, Vol.24 (8), p.398-407

2013

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Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans

Scientific reports, 2021-05, Vol.11 (1), p.11283-11283, Article 11283

2021

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Glucolipotoxicity of the pancreatic beta cell

Biochimica et biophysica acta, 2010-03, Vol.1801 (3), p.289-298

2010

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The Role and Future of FFA1 as a Therapeutic Target

Free Fatty Acid Receptors, 2017-01, Vol.236, p.159-180

2017

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Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

PloS one, 2012-04, Vol.7 (4), p.e36200

2012

Volltextzugriff (PDF)

β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

Diabetes (New York, N.Y.), 2004-02, Vol.53 (suppl 1), p.S119-S124

2004

Volltextzugriff (PDF)

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death

Diabetes (New York, N.Y.), 2010-02, Vol.59 (2), p.440-447

2010

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Considerations and guidelines for mouse metabolic phenotyping in diabetes research

Diabetologia, 2018-03, Vol.61 (3), p.526-538

2018

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Modulating GPR40: therapeutic promise and potential in diabetes

Drug discovery today, 2013-12, Vol.18 (23-24), p.1301-1308

2013

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Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

Diabetes (New York, N.Y.), 2009-11, Vol.58 (11), p.2607-2615

2009

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Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats

Diabetologia, 2017-05, Vol.60 (5), p.879-888

2017

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Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice

The international journal of neuropsychopharmacology, 2016-07, Vol.19 (7), p.pyw014

2016

Volltextzugriff (PDF)

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

Diabetes (New York, N.Y.), 2008-09, Vol.57 (9), p.2432-2437

2008

Volltextzugriff (PDF)

The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation

The Journal of biological chemistry, 2013-03, Vol.288 (9), p.6542-6551

2013

Volltextzugriff (PDF)

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Diabetes (New York, N.Y.), 2019-02, Vol.68 (2), p.239-240

2019

Volltextzugriff (PDF)

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

Cell reports (Cambridge), 2023-05, Vol.42 (5), p.112500-112500, Article 112500

2023

Volltextzugriff (PDF)

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

Diabetes (New York, N.Y.), 2007-04, Vol.56 (4), p.1087-1094

2007

Volltextzugriff (PDF)

Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

Molecular metabolism (Germany), 2021-03, Vol.45, p.101166-101166, Article 101166

2021

Volltextzugriff (PDF)

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (7), p.2376-2381

2012

Volltextzugriff (PDF)

Palmitate Inhibits Insulin Gene Expression by Altering PDX-1 Nuclear Localization and Reducing MafA Expression in Isolated Rat Islets of Langerhans

The Journal of biological chemistry, 2005-09, Vol.280 (37), p.32413-32418

2005

Volltextzugriff (PDF)

Editorial: Pancreas Imaging Across the Spectrum

Frontiers in endocrinology (Lausanne), 2021-01, Vol.12, p.832519-832519

2021

Volltextzugriff (PDF)

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

Molecular metabolism (Germany), 2014-12, Vol.3 (9), p.848-854

2014

Volltextzugriff (PDF)

Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide Synthesis

The Journal of biological chemistry, 2003-08, Vol.278 (32), p.30015-30021

2003

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Fatty Acids and Insulin Secretion: From FFAR and Near?

Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans

Glucolipotoxicity of the pancreatic beta cell

The Role and Future of FFA1 as a Therapeutic Target

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death

Considerations and guidelines for mouse metabolic phenotyping in diabetes research

Modulating GPR40: therapeutic promise and potential in diabetes

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats

Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Palmitate Inhibits Insulin Gene Expression by Altering PDX-1 Nuclear Localization and Reducing MafA Expression in Isolated Rat Islets of Langerhans

Editorial: Pancreas Imaging Across the Spectrum

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide Synthesis

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