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Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1 H -benzo[ d ]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy

Journal of medicinal chemistry, 2024-09, Vol.67 (17), p.15246-15267

2024

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Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Nature communications, 2024-09, Vol.15 (1), p.7772-20, Article 7772

2024

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Porcine deltacoronavirus nucleocapsid protein interacts with the Grb2 through its proline-rich motifs to induce activation of the Raf-MEK-ERK signal pathway and promote virus replication

Journal of general virology, 2024-08, Vol.105 (8)

2024

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Preclinical Evaluation of a Radiolabeled Pan-RAF Inhibitor for RAF-Specific PET/CT Imaging

Molecular pharmaceutics, 2024-10, Vol.21 (10), p.5247-5254

2024

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Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells

Cell reports (Cambridge), 2024-09, Vol.43 (9), p.114710, Article 114710

2024

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Raddeanin A augments the cytotoxicity of natural killer cells against chronic myeloid leukaemia cells by modulating MAPK and Ras/Raf signalling pathways

Journal of cellular and molecular medicine, 2024-08, Vol.28 (16), p.e70016-n/a

2024

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Peptidomic analysis reveals novel peptide PDLC promotes cell proliferation in hepatocellular carcinoma via Ras/Raf/MEK/ERK pathway

Scientific reports, 2024-08, Vol.14 (1), p.18757-12, Article 18757

2024

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Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway

Molecular medicine reports, 2024-12, Vol.30 (6), Article 223

2024

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Impact of protein and small molecule interactions on kinase conformations

eLife, 2024-08, Vol.13

2024

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Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib)

Cell communication and signaling, 2024-08, Vol.22 (1), p.410-21

2024

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MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation

Cancer letters, 2024-10, Vol.602, p.217201, Article 217201

2024

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Targeting the multifaceted BRAF in cancer: New directions

Oncotarget, 2024-07, Vol.15 (1), p.486-492

2024

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The mTOR pathway controls phosphorylation of BRAF at T401

Cell communication and signaling, 2024-09, Vol.22 (1), p.428-13, Article 428

2024

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SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

Nature communications, 2024-09, Vol.15 (1), p.8002-20, Article 8002

2024

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Phenylephrine Enhances the Mitogenic Effect of S-Allyl-L-cysteine on Primary Cultured Hepatocytes through Protein Kinase C-Induced B-Raf Phosphorylation

Biological and Pharmaceutical Bulletin, 2024/09/27, Vol.47(9), pp.1565-1574

2024

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MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK

Cancer immunology research, 2024-10, Vol.12 (10), p.1452-1467

2024

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FAK loss reduces BRAF V600E -induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

eLife, 2024-06, Vol.13

2024

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TRKing down drug resistance in NTRK fusion‐positive cancers

The Journal of pathology, 2024-10, Vol.264 (2), p.129-131

2024

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Treatment resistance to melanoma therapeutics on a single cell level

Scientific reports, 2024-09, Vol.14 (1), p.21915-14, Article 21915

2024

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Reversible control of kinase signaling through chemical-induced dephosphorylation

Communications biology, 2024-08, Vol.7 (1), p.1073-15, Article 1073

2024

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Mechanism of gabapentinoid potentiation of opioid effects on cyclic AMP signaling in neuropathic pain

Proceedings of the National Academy of Sciences - PNAS, 2024-08, Vol.121 (34), p.e2405465121

2024

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Promotion of Raf-1/ASK1 complex formation by corylin inhibits cell apoptosis in myocardial ischemia/reperfusion injury

International immunopharmacology, 2024-10, Vol.140, p.112921, Article 112921

2024

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BRAF and MEK inhibitor targeted therapy in papillary craniopharyngiomas: a cohort study

European journal of endocrinology, 2024-08, Vol.191 (2), p.251

2024

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1 H and 31 P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma

Cells (Basel, Switzerland), 2024-07, Vol.13 (14)

2024

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Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation

Acta neuropathologica communications, 2024-08, Vol.12 (1), p.124-12, Article 124

2024

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Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1 H -benzo[ d ]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Porcine deltacoronavirus nucleocapsid protein interacts with the Grb2 through its proline-rich motifs to induce activation of the Raf-MEK-ERK signal pathway and promote virus replication

Preclinical Evaluation of a Radiolabeled Pan-RAF Inhibitor for RAF-Specific PET/CT Imaging

Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells

Raddeanin A augments the cytotoxicity of natural killer cells against chronic myeloid leukaemia cells by modulating MAPK and Ras/Raf signalling pathways

Peptidomic analysis reveals novel peptide PDLC promotes cell proliferation in hepatocellular carcinoma via Ras/Raf/MEK/ERK pathway

Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway

Impact of protein and small molecule interactions on kinase conformations

Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib)

MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation

Targeting the multifaceted BRAF in cancer: New directions

The mTOR pathway controls phosphorylation of BRAF at T401

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

Phenylephrine Enhances the Mitogenic Effect of S-Allyl-L-cysteine on Primary Cultured Hepatocytes through Protein Kinase C-Induced B-Raf Phosphorylation

MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK

FAK loss reduces BRAF V600E -induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

TRKing down drug resistance in NTRK fusion‐positive cancers

Treatment resistance to melanoma therapeutics on a single cell level

Reversible control of kinase signaling through chemical-induced dephosphorylation

Mechanism of gabapentinoid potentiation of opioid effects on cyclic AMP signaling in neuropathic pain

Promotion of Raf-1/ASK1 complex formation by corylin inhibits cell apoptosis in myocardial ischemia/reperfusion injury

BRAF and MEK inhibitor targeted therapy in papillary craniopharyngiomas: a cohort study

1 H and 31 P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma

Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation

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