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Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Scientific reports, 2016-07, Vol.6 (1), p.30377, Article 30377

2016

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Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance

Organic letters, 2014-11, Vol.16 (21), p.5640-5643

2014

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RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides

Nucleic acid therapeutics, 2019-02, Vol.29 (1), p.44-50

2019

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S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Frontiers in immunology, 2021-12, Vol.12, p.803090-803090

2021

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Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region

Nucleic acid therapeutics, 2017-08, Vol.27 (4), p.232-237

2017

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Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Journal of organic chemistry, 2017-01, Vol.82 (1), p.12-24

2017

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Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma

European journal of pharmacology, 2015-10, Vol.765, p.15-23

2015

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Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins

Analytical Sciences, 2015/12/10, Vol.31(12), pp.1255-1260

2015

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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure

Organic & biomolecular chemistry, 2016-01, Vol.14 (27), p.6531-6538

2016

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Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides

Nucleic acid therapeutics, 2018-10, Vol.28 (5), p.312-317

2018

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Abstract 1916: Lymph node targeting double stranded CpG act effective adjuvant in cancer peptide vaccine

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1916-1916

2021

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Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B

The Journal of pharmacology and experimental therapeutics, 2016-05, Vol.357 (2), p.320-330

2016

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Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Angewandte Chemie International Edition, 1998-04, Vol.37 (7), p.973-975

1998

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Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4923-4927

2011

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Synthesis and Evaluation of Diaryl Thiazole Derivatives that Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Journal of medicinal chemistry, 2011-06, Vol.54 (13), p.4923-4927

2011

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A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

Chemistry & biology, 2009-08, Vol.16 (8), p.882-892

2009

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Total Synthesis of Terprenin, a Novel Immunosuppressive p-Terphenyl Derivative

Journal of organic chemistry, 1998-08, Vol.63 (17), p.5831-5837

1998

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New γ-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity

European journal of medicinal chemistry, 2000-05, Vol.35 (5), p.529-534

2000

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Synthesis and Evaluation of Novel Fluorinated Methotrexate Derivatives for Application to Rheumatoid Arthritis Treatment

Journal of medicinal chemistry, 1997-09, Vol.40 (20), p.3280-3291

1997

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Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin‐E‐Suppressivum

Angewandte Chemie, 1998-04, Vol.110 (7), p.1015-1017

1998

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ChemInform Abstract: New γ-Fluoromethotrexates Modified in the Pteridine Ring: Synthesis and in vitro Immunosuppressive Activity

ChemInform, 2000-09, Vol.31 (39), p.no-no

2000

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Dinitrogen Fixation by Vanadium Complexes with a Triamidoamine Ligand

Inorganic chemistry, 2018-10, Vol.57 (19), p.11884-11894

2018

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Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

Developmental cell, 2008-05, Vol.14 (5), p.689-699

2008

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Successful treatment of lymphoid blastic crisis in chronic myelogenous leukemia with the additional bcr/abl transcript using imatinib-combined chemotherapy and high-dose chemotherapy with allogeneic bone marrow stem cell transplantation

International journal of hematology, 2011-12, Vol.94 (6), p.561-566

2011

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Characterization of interface of Al–Ni/a-Si for thin film transistor using high-resolution Rutherford backscattering spectrometry

Micron (Oxford, England : 1993), 2009, Vol.40 (1), p.66-69

2009

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Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance

RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides

S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma

Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure

Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides

Abstract 1916: Lymph node targeting double stranded CpG act effective adjuvant in cancer peptide vaccine

Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Synthesis and Evaluation of Diaryl Thiazole Derivatives that Inhibit Activation of Sterol Regulatory Element-Binding Proteins

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

Total Synthesis of Terprenin, a Novel Immunosuppressive p-Terphenyl Derivative

New γ-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity

Synthesis and Evaluation of Novel Fluorinated Methotrexate Derivatives for Application to Rheumatoid Arthritis Treatment

Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin‐E‐Suppressivum

ChemInform Abstract: New γ-Fluoromethotrexates Modified in the Pteridine Ring: Synthesis and in vitro Immunosuppressive Activity

Dinitrogen Fixation by Vanadium Complexes with a Triamidoamine Ligand

Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

Successful treatment of lymphoid blastic crisis in chronic myelogenous leukemia with the additional bcr/abl transcript using imatinib-combined chemotherapy and high-dose chemotherapy with allogeneic bone marrow stem cell transplantation

Characterization of interface of Al–Ni/a-Si for thin film transistor using high-resolution Rutherford backscattering spectrometry

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