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Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1639-1647

2009

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A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

The Journal of infectious diseases, 2014-01, Vol.209 (2), p.275-284

2014

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Assessment of topographic brachial plexus nerves variations at the axilla using ultrasonography

British journal of anaesthesia : BJA, 2009-10, Vol.103 (4), p.606-612

2009

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Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.1982-1989

2011

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Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Antimicrobial Agents and Chemotherapy, 2008-10, Vol.52 (10), p.3710-3717

2008

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Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4914-4921

2012

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Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

Journal of medicinal chemistry, 2012-03, Vol.55 (6), p.2803-2810

2012

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Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3021-3028

2013

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Repurposing Infectious Disease Hits as Anti-Cryptosporidium Leads

ACS infectious diseases, 2021-05, Vol.7 (5), p.1275-1282

2021

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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Molecular microbiology, 2008-04, Vol.68 (1), p.37-50

2008

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Identification of CD46 Binding Sites within the Adenovirus Serotype 35 Fiber Knob

Journal of Virology, 2007-12, Vol.81 (23), p.12785-12792

2007

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Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

Antimicrobial agents and chemotherapy, 2019-04, Vol.63 (4)

2019

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Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection

Antimicrobial agents and chemotherapy, 2021-05, Vol.65 (6)

2021

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Genomic-scale prioritization of drug targets: the TDR Targets database

Nature reviews. Drug discovery, 2008-11, Vol.7 (11), p.900-907

2008

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Effects of hypoxic interval training on cycling performance

Medicine and science in sports and exercise, 2005, Vol.37 (1), p.138-146

2005

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Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

Antimicrobial agents and chemotherapy, 2017-11, Vol.61 (11)

2017

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Second Generation Analogues of the Cancer Drug Clinical Candidate Tipifarnib for Anti-Chagas Disease Drug Discovery

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.3887-3898

2010

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Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites

Antimicrobial agents and chemotherapy, 2015-11, Vol.59 (11), p.7128-7131

2015

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Urea-Based Inhibitors of Trypanosoma brucei Methionyl-tRNA Synthetase: Selectivity and in Vivo Characterization

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6342-6351

2012

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Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

Antimicrobial Agents and Chemotherapy, 2007-10, Vol.51 (10), p.3659-3671

2007

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Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase

Journal of medicinal chemistry, 2006-10, Vol.49 (20), p.5939-5946

2006

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Reengineering CCA-adding enzymes to function as (U,G)- or dCdCdA-adding enzymes or poly(C,A) and poly(U,G) polymerases

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (1), p.54-59

2007

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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

PLoS neglected tropical diseases, 2014-04, Vol.8 (4), p.e2775

2014

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Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5264-5267

2012

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Glycaemic dysregulation in nondiabetic patients after major lower limb prosthetic surgery

Diabetes & metabolism, 2009-02, Vol.35 (1), p.43-48

2009

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Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

Assessment of topographic brachial plexus nerves variations at the axilla using ultrasonography

Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

Repurposing Infectious Disease Hits as Anti-Cryptosporidium Leads

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Identification of CD46 Binding Sites within the Adenovirus Serotype 35 Fiber Knob

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection

Genomic-scale prioritization of drug targets: the TDR Targets database

Effects of hypoxic interval training on cycling performance

Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

Second Generation Analogues of the Cancer Drug Clinical Candidate Tipifarnib for Anti-Chagas Disease Drug Discovery

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites

Urea-Based Inhibitors of Trypanosoma brucei Methionyl-tRNA Synthetase: Selectivity and in Vivo Characterization

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase

Reengineering CCA-adding enzymes to function as (U,G)- or dCdCdA-adding enzymes or poly(C,A) and poly(U,G) polymerases

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

Glycaemic dysregulation in nondiabetic patients after major lower limb prosthetic surgery

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