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Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance-Implications for IGF-II and IGF-IR-Targeted Therapy

Clinical cancer research, 2014-05, Vol.20 (10), p.2651-2662

2014

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The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction

American journal of physiology: endocrinology and metabolism, 2016-01, Vol.310 (1), p.E24-E31

2016

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Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

The Journal of neuroscience, 2015-08, Vol.35 (33), p.11500-11513

2015

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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

Cancer research (Chicago, Ill.), 2011-02, Vol.71 (3), p.1029-1040

2011

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Gli1+ progenitors mediate bone anabolic function of teriparatide via Hh and Igf signaling

Cell reports (Cambridge), 2021-08, Vol.36 (7), p.109542-109542, Article 109542

2021

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Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses

Oncotarget, 2015-06, Vol.6 (18), p.16084-16105

2015

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High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

Clinical cancer research, 2011-04, Vol.17 (8), p.2314-2327

2011

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Therapeutic Targeting of the IGF Axis

Cells (Basel, Switzerland), 2019-08, Vol.8 (8), p.895

2019

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Insulin-Like Growth Factor (IGF) Binding Protein 2 Functions Coordinately with Receptor Protein Tyrosine Phosphatase β and the IGF-I Receptor To Regulate IGF-I-Stimulated Signaling

Molecular and Cellular Biology, 2012-10, Vol.32 (20), p.4116-4130

2012

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Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling

Diabetes (New York, N.Y.), 2023-10, Vol.72 (10), p.1460-1469

2023

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IGF-I 3′ Untranslated Region: Strain-Specific Polymorphisms and Motifs Regulating IGF-I in Osteoblasts

Endocrinology (Philadelphia), 2013-01, Vol.154 (1), p.253-262

2013

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In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

Cancer cell, 2004-03, Vol.5 (3), p.231-239

2004

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Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion

The Journal of biological chemistry, 2014-02, Vol.289 (8), p.4626-4633

2014

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Suppression of IGF‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging

Aging cell, 2015-10, Vol.14 (5), p.847-856

2015

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Effect of IGF‐I in the Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in the Presence or Absence of TGF‐β Signaling

Journal of bone and mineral research, 2006-04, Vol.21 (4), p.626-636

2006

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Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

Endocrinology (Philadelphia), 2014-05, Vol.155 (5), p.1793-1805

2014

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Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Gut, 2017-03, Vol.66 (3), p.530-540

2017

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Effects of IGF‐1 isoforms on muscle growth and sarcopenia

Aging cell, 2019-06, Vol.18 (3), p.e12954-n/a

2019

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Insulin and IGF receptor signalling in neural-stem-cell homeostasis

Nature reviews. Endocrinology, 2015-03, Vol.11 (3), p.161-170

2015

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The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nature medicine, 2012-11, Vol.18 (11), p.1643-1650

2012

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Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts

Gut, 2005-05, Vol.54 (5), p.591-600

2005

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IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

Aging cell, 2015-12, Vol.14 (6), p.1034-1044

2015

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Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

Diabetes (New York, N.Y.), 2017-01, Vol.66 (1), p.64-74

2017

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Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation

FEBS letters, 2002-07, Vol.522 (1), p.156-160

2002

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Exogenous GLP-2 and IGF-I induce a differential intestinal response in IGF binding protein-3 and -5 double knockout mice

American journal of physiology: Gastrointestinal and liver physiology, 2012-04, Vol.302 (8), p.G794-G804

2012

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Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance-Implications for IGF-II and IGF-IR-Targeted Therapy

The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

Gli1+ progenitors mediate bone anabolic function of teriparatide via Hh and Igf signaling

Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

Therapeutic Targeting of the IGF Axis

Insulin-Like Growth Factor (IGF) Binding Protein 2 Functions Coordinately with Receptor Protein Tyrosine Phosphatase β and the IGF-I Receptor To Regulate IGF-I-Stimulated Signaling

Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling

IGF-I 3′ Untranslated Region: Strain-Specific Polymorphisms and Motifs Regulating IGF-I in Osteoblasts

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion

Suppression of IGF‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging

Effect of IGF‐I in the Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in the Presence or Absence of TGF‐β Signaling

Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

Insulin and IGF receptor signalling in neural-stem-cell homeostasis

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts

IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation

Exogenous GLP-2 and IGF-I induce a differential intestinal response in IGF binding protein-3 and -5 double knockout mice

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