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Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (39), p.E5381-E5390

2015

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Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (15), p.3975-3980

2017

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Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (52), p.20852-20857

2008

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MicroRNA Profiling Reveals Distinct Signatures in B Cell Chronic Lymphocytic Leukemias

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (32), p.11755-11760

2004

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Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13906-13911

2014

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Genetic modifiers of EGFR dependence in non-small cell lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18661-18666

2014

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Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (49), p.19238-19243

2007

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Detection of a rare BCR–ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS)

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16190-16195

2012

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Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (43), p.18563-18568

2010

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Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (8), p.e2213090120-e2213090120

2023

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SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

Proceedings of the National Academy of Sciences - PNAS, 2023-11, Vol.120 (47), p.e2313137120-e2313137120

2023

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T-cell receptor complex is essential for Fas signal transduction

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15105-15110

2010

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WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (30), p.e2203743119-e2203743119

2022

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Activity of Dual SRC-ABL Inhibitors Highlights the Role of BCR/ABL Kinase Dynamics in Drug Resistance

Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (24), p.9244-9249

2006

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A Non-ATP-Competitive Inhibitor of BCR-ABL Overrides Imatinib Resistance

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (6), p.1992-1997

2005

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Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (38), p.16691-16696

2010

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Two-step release of kinase autoinhibition in discoidin domain receptor 1

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (36), p.22051-22060

2020

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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.3493-3498

2015

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Phosphatidylinositol 3-kinase-γ Activates Bruton's Tyrosine Kinase in Concert with Src Family Kinases

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (25), p.13820-13825

1997

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mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (37), p.14592-14597

2007

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Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (5), p.1643-1648

2012

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Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (40), p.E8448-E8457

2017

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Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (20), p.10025-10030

2019

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Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (33), p.13283-13288

2007

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sharp T-cell antigen receptor signaling threshold for T-cell proliferation

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.E3679-E3688

2014

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Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

MicroRNA Profiling Reveals Distinct Signatures in B Cell Chronic Lymphocytic Leukemias

Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

Genetic modifiers of EGFR dependence in non-small cell lung cancer

Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation

Detection of a rare BCR–ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS)

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor

Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

T-cell receptor complex is essential for Fas signal transduction

WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis

Activity of Dual SRC-ABL Inhibitors Highlights the Role of BCR/ABL Kinase Dynamics in Drug Resistance

A Non-ATP-Competitive Inhibitor of BCR-ABL Overrides Imatinib Resistance

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Two-step release of kinase autoinhibition in discoidin domain receptor 1

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

Phosphatidylinositol 3-kinase-γ Activates Bruton's Tyrosine Kinase in Concert with Src Family Kinases

mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

sharp T-cell antigen receptor signaling threshold for T-cell proliferation

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