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AMG 837: A potent, orally bioavailable GPR40 agonist

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1267-1270

2012

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Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1)

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5748-5751

2012

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Synthesis and optimization of 2-pyridin-3-yl-benzo[ d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4743-4746

2009

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Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (18), p.2515-2519

2001

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Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase

Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (11), p.1297-1298

2000

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Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase

Bioorganic & medicinal chemistry letters, 1997-03, Vol.7 (5), p.505-510

1997

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Structure–activity and crystallographic analysis of benzophenone derivatives—the potential anticancer agents

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (1), p.101-105

2003

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(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (21), p.2759-2764

1997

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Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.219-222

2001

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Synthesis of 2,3,4a, 11b-tetrahydro-oxazino[2,3-c]benzopyran-9-carbonitriles as ATP-sensitive potassium channel openers

Bioorganic & medicinal chemistry letters, 1998-03, Vol.8 (5), p.463-468

1998

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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1721-1727

2004

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Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA2

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.868-871

2012

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Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.1011-1014

2004

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Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2421-2425

2000

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Biaryl amide glucagon receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2047-2050

2004

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Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: Side chain exploration

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1864-1868

2006

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(4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.87-90

2004

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Facile synthesis of metal-chelating peptides on chip for protein array

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1987-1990

2004

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trans-2,6-, 3,6- and 4,6-Diaza-5,6,6a,7,8,12b-hexahydrobenzo[ C]phenanthrene-10,11-diols as dopamine agonists

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (10), p.1341-1346

1999

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Anti-aids agents. 29. Anti-HIV activity of modified podophyllotoxin derivatives

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (22), p.2897-2902

1997

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Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232 : increased dopamine D3 receptor preference and improved pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 1994-03, Vol.4 (5), p.689-694

1994

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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3706-3712

2006

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Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.3058-3062

2005

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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4538-4544

2007

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Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6390-6393

2008

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AMG 837: A potent, orally bioavailable GPR40 agonist

Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1)

Synthesis and optimization of 2-pyridin-3-yl-benzo[ d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase

Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase

Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase

Structure–activity and crystallographic analysis of benzophenone derivatives—the potential anticancer agents

(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists

Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue

Synthesis of 2,3,4a, 11b-tetrahydro-oxazino[2,3-c]benzopyran-9-carbonitriles as ATP-sensitive potassium channel openers

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA2

Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica

Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor

Biaryl amide glucagon receptor antagonists

Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: Side chain exploration

(4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors

Facile synthesis of metal-chelating peptides on chip for protein array

trans-2,6-, 3,6- and 4,6-Diaza-5,6,6a,7,8,12b-hexahydrobenzo[ C]phenanthrene-10,11-diols as dopamine agonists

Anti-aids agents. 29. Anti-HIV activity of modified podophyllotoxin derivatives

Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232 : increased dopamine D3 receptor preference and improved pharmacokinetic properties

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

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