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Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

Antimicrobial agents and chemotherapy, 2019-10, Vol.63 (10)

2019

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Prospects for Antibacterial Discovery and Development

Journal of the American Chemical Society, 2021-12, Vol.143 (50), p.21127-21142

2021

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Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity

The Journal of biological chemistry, 2018-08, Vol.293 (32), p.12606-12618

2018

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Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑Lactamases

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12511-12525

2020

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Characteristics of extended-spectrum β-lactamase (ESBL)- and pAmpC beta-lactamase-producing Enterobacteriaceae of water samples in Tunisia

The Science of the total environment, 2016-04, Vol.550, p.1103-1109

2016

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New Conformations of Acylation Adducts of Inhibitors of β‑Lactamase from Mycobacterium tuberculosis

Biochemistry (Easton), 2019-02, Vol.58 (7), p.997-1009

2019

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Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Molecular microbiology, 2017-11, Vol.106 (3), p.492-504

2017

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Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus

Scientific reports, 2020-01, Vol.10 (1), p.928, Article 928

2020

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Meat and Fish as Sources of Extended-Spectrum β-Lactamase-Producing Escherichia coli, Cambodia

Emerging infectious diseases, 2019-01, Vol.25 (1), p.126-131

2019

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β-Lactamase inhibition by avibactam in Mycobacterium abscessus

Journal of antimicrobial chemotherapy, 2015-04, Vol.70 (4), p.1051-1058

2015

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Progress toward inhibitors of metallo-β-lactamases

Future medicinal chemistry, 2017-05, Vol.9 (7), p.673-691

2017

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Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

Antimicrobial agents and chemotherapy, 2016-02, Vol.60 (2), p.752-756

2016

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β-Lactamases and β-Lactamase Inhibitors in the 21st Century

Journal of molecular biology, 2019-08, Vol.431 (18), p.3472-3500

2019

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Serendipitous discovery of aryl boronic acids as β-lactamase inhibitors

Bioorganic & medicinal chemistry letters, 2020-01, Vol.30 (2), p.126795-126795, Article 126795

2020

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Faropenem reacts with serine and metallo-β-lactamases to give multiple products

European journal of medicinal chemistry, 2021-04, Vol.215, p.113257-113257, Article 113257

2021

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Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations

Journal of antimicrobial chemotherapy, 2016-10, Vol.71 (10), p.2848-2855

2016

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Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030

Antimicrobial agents and chemotherapy, 2016-03, Vol.60 (3), p.1760-1766

2016

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Interdomain flexibility and interfacial integrity of β-lactamase inhibitory protein (BLIP) modulate its binding to class A β-lactamases

The Journal of biological chemistry, 2021-08, Vol.297 (2), p.100980-100980, Article 100980

2021

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Deep Sequencing of a Systematic Peptide Library Reveals Conformationally‐Constrained Protein Interface Peptides that Disrupt a Protein‐Protein Interaction

Chembiochem : a European journal of chemical biology, 2022-02, Vol.23 (3), p.e202100504-n/a

2022

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Investigation of Dipicolinic Acid Isosteres for the Inhibition of Metallo‐β‐Lactamases

ChemMedChem, 2019-07, Vol.14 (13), p.1271-1282

2019

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Loss of activity of ceftazidime-avibactam due to MexAB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis

International journal of antimicrobial agents, 2018-11, Vol.52 (5), p.697-701

2018

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WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases

Journal of antimicrobial chemotherapy, 2017-06, Vol.72 (6), p.1688-1695

2017

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Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β‐lactamase inhibitor

Chemical biology & drug design, 2021-10, Vol.98 (4), p.481-492

2021

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Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Scientific reports, 2017-12, Vol.7 (1), p.17716-15, Article 17716

2017

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Inhibition of β-lactamases of mycobacteria by avibactam and clavulanate

Journal of antimicrobial chemotherapy, 2017-04, Vol.72 (4), p.1081-1088

2017

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Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

Prospects for Antibacterial Discovery and Development

Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑Lactamases

Characteristics of extended-spectrum β-lactamase (ESBL)- and pAmpC beta-lactamase-producing Enterobacteriaceae of water samples in Tunisia

New Conformations of Acylation Adducts of Inhibitors of β‑Lactamase from Mycobacterium tuberculosis

Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus

Meat and Fish as Sources of Extended-Spectrum β-Lactamase-Producing Escherichia coli, Cambodia

β-Lactamase inhibition by avibactam in Mycobacterium abscessus

Progress toward inhibitors of metallo-β-lactamases

Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

Serendipitous discovery of aryl boronic acids as β-lactamase inhibitors

Faropenem reacts with serine and metallo-β-lactamases to give multiple products

Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations

Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030

Interdomain flexibility and interfacial integrity of β-lactamase inhibitory protein (BLIP) modulate its binding to class A β-lactamases

Deep Sequencing of a Systematic Peptide Library Reveals Conformationally‐Constrained Protein Interface Peptides that Disrupt a Protein‐Protein Interaction

Investigation of Dipicolinic Acid Isosteres for the Inhibition of Metallo‐β‐Lactamases

Loss of activity of ceftazidime-avibactam due to MexAB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis

WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases

Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β‐lactamase inhibitor

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Inhibition of β-lactamases of mycobacteria by avibactam and clavulanate

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