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Identification of a Chemical Probe for Bromo and Extra C‑Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9831-9837

2012

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Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4800-4811

2016

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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1130-1152

2018

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Genetic testing and diagnosis of inherited retinal diseases

Orphanet journal of rare diseases, 2021-12, Vol.16 (1), p.514-514, Article 514

2021

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Frequency of Usher syndrome in two pediatric populations: Implications for genetic screening of deaf and hard of hearing children

Genetics in medicine, 2010-08, Vol.12 (8), p.512-516

2010

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Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I

Journal of the American Chemical Society, 2009-11, Vol.131 (44), p.16036-16038

2009

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Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet−Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan

Journal of the American Chemical Society, 2010-06, Vol.132 (24), p.8506-8512

2010

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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Total Synthesis of Complestatin: Development of a Pd(0)-Mediated Indole Annulation for Macrocyclization

Journal of the American Chemical Society, 2010-06, Vol.132 (22), p.7776-7783

2010

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Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Genome medicine, 2020-06, Vol.12 (1), p.55-55, Article 55

2020

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Clinical and Electrophysiologic Characterization of Paraneoplastic and Autoimmune Retinopathies Associated With Antienolase Antibodies

American journal of ophthalmology, 2005-05, Vol.139 (5), p.780-794

2005

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(S)‐4‐Amino‐5‐phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR

Protein science, 2020-08, Vol.29 (8), p.1816-1828

2020

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Low-dose IL-2 reduces IL-21 + T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Nature communications, 2022-11, Vol.13 (1), p.7324-7324, Article 7324

2022

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Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

Nature chemical biology, 2006-02, Vol.2 (2), p.79-82

2006

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The phenotype of Severe Early Childhood Onset Retinal Dystrophy (SECORD) from mutation of RPE65 and differentiation from Leber congenital amaurosis

Investigative ophthalmology & visual science, 2011-01, Vol.52 (1), p.292-302

2011

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Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis

Gastroenterology (New York, N.Y. 1943), 2021-10, Vol.161 (4), p.1229-1244.e9

2021

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Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams

Organic letters, 2015-11, Vol.17 (21), p.5204-5207

2015

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CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

Communications biology, 2020-07, Vol.3 (1), p.375, Article 375

2020

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Asymmetric Total Synthesis of (+)- and ent-(−)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer

Journal of the American Chemical Society, 2006-12, Vol.128 (49), p.15683-15696

2006

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An evidence‐based practice guideline of the National Society of Genetic Counselors for telehealth genetic counseling

Journal of genetic counseling, 2023-02, Vol.32 (1), p.4-17

2023

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The current status of molecular diagnosis of inherited retinal dystrophies

Current opinion in ophthalmology, 2015-07, Vol.26 (5), p.346-351

2015

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Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease

Investigative ophthalmology & visual science, 2012-12, Vol.53 (13), p.8232-8237

2012

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Photochemical Generation of Ribose Abasic Sites in RNA Oligonucleotides

Organic letters, 2005-04, Vol.7 (8), p.1493-1496

2005

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A Unique Class of Duocarmycin and CC-1065 Analogues Subject to Reductive Activation

Journal of the American Chemical Society, 2007-12, Vol.129 (49), p.15391-15397

2007

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Epigenetic drugs that do not target enzyme activity

Drug discovery today. Technologies, 2014-06, Vol.12, p.e29-e34

2014

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Identification of a Chemical Probe for Bromo and Extra C‑Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Genetic testing and diagnosis of inherited retinal diseases

Frequency of Usher syndrome in two pediatric populations: Implications for genetic screening of deaf and hard of hearing children

Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I

Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet−Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Total Synthesis of Complestatin: Development of a Pd(0)-Mediated Indole Annulation for Macrocyclization

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Clinical and Electrophysiologic Characterization of Paraneoplastic and Autoimmune Retinopathies Associated With Antienolase Antibodies

(S)‐4‐Amino‐5‐phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR

Low-dose IL-2 reduces IL-21 + T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

The phenotype of Severe Early Childhood Onset Retinal Dystrophy (SECORD) from mutation of RPE65 and differentiation from Leber congenital amaurosis

Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis

Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

Asymmetric Total Synthesis of (+)- and ent-(−)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer

An evidence‐based practice guideline of the National Society of Genetic Counselors for telehealth genetic counseling

The current status of molecular diagnosis of inherited retinal dystrophies

Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease

Photochemical Generation of Ribose Abasic Sites in RNA Oligonucleotides

A Unique Class of Duocarmycin and CC-1065 Analogues Subject to Reductive Activation

Epigenetic drugs that do not target enzyme activity

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