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SMAC mimetics as potential cancer therapeutics in myeloid malignancies

British journal of haematology, 2019-04, Vol.185 (2), p.219-231

2019

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Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML

Blood, 2021-10, Vol.138 (17), p.1637-1641

2021

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Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

Science translational medicine, 2016-09, Vol.8 (355), p.355ra117

2016

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ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia

Nature communications, 2023-09, Vol.14 (1), p.5709-16, Article 5709

2023

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EXABS-147-AML How Do We Overcome Resistance to Venetoclax

Clinical lymphoma, myeloma and leukemia, 2022-10, Vol.22 Suppl 2, p.S55-S57

2022

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An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML

Cancer research (Chicago, Ill.), 2019-03, Vol.79 (6), p.1165-1177

2019

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Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

Cells (Basel, Switzerland), 2023-04, Vol.12 (8), p.1128

2023

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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia

Haematologica (Roma), 2022-06, Vol.107 (6), p.1311-1322

2022

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Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model

Haematologica (Roma), 2020-05, Vol.105 (5), p.1274-1284

2020

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Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3 -Mutant Acute Myeloid Leukemia

Clinical cancer research, 2018-05, Vol.24 (10), p.2417-2429

2018

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A novel HDAC inhibitor chidamide combined with imatinib synergistically targets tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Biomedicine & pharmacotherapy, 2020-09, Vol.129, p.110390, Article 110390

2020

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Combination of dasatinib and venetoclax in newly diagnosed chronic phase chronic myeloid leukemia

Cancer, 2024-08, Vol.130 (15), p.2652-2659

2024

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miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways

Cell death & disease, 2016-09, Vol.7 (9), p.e2371-e2371

2016

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Impact of FLT3-ITD allele ratio and ITD length on therapeutic outcome in cytogenetically normal AML patients without NPM1 mutation

Bone marrow transplantation (Basingstoke), 2020-04, Vol.55 (4), p.740-748

2020

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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia

Leukemia, 2024-04, Vol.38 (4), p.729-740

2024

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Survivin is highly expressed in CD34+38− leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

Blood, 2012-07, Vol.120 (1), p.173-180

2012

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Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

Journal of translational medicine, 2021-03, Vol.19 (1), p.117-117, Article 117

2021

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Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Oncotarget, 2014-10, Vol.5 (19), p.9118-9132

2014

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Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.879-889

2022

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Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

Blood, 2006-07, Vol.108 (2), p.630-637

2006

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Dasatinib induces autophagic cell death in human ovarian cancer

Cancer, 2010-11, Vol.116 (21), p.4980-4990

2010

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Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

Blood cancer journal (New York), 2023-04, Vol.13 (1), p.57-57, Article 57

2023

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Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells

Blood, 2023-09, Vol.142 (12), p.1056-1070

2023

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Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

Blood, 2008-04, Vol.111 (7), p.3742-3750

2008

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Glioblastoma and acute myeloid leukemia: malignancies with striking similarities

Journal of neuro-oncology, 2018, Vol.136 (2), p.223-231

2018

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SMAC mimetics as potential cancer therapeutics in myeloid malignancies

Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia

EXABS-147-AML How Do We Overcome Resistance to Venetoclax

An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML

Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia

Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model

Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3 -Mutant Acute Myeloid Leukemia

A novel HDAC inhibitor chidamide combined with imatinib synergistically targets tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Combination of dasatinib and venetoclax in newly diagnosed chronic phase chronic myeloid leukemia

miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways

Impact of FLT3-ITD allele ratio and ITD length on therapeutic outcome in cytogenetically normal AML patients without NPM1 mutation

Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia

Survivin is highly expressed in CD34+38− leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

Dasatinib induces autophagic cell death in human ovarian cancer

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

Glioblastoma and acute myeloid leukemia: malignancies with striking similarities

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