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Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (34), p.E4976-E4984

2016

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On the role of sidechain size and charge in the aggregation of A β 42 with familial mutations

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (26), p.E5849

2018

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Differences in the free energies between the excited states of A β 40 and A β 42 monomers encode their aggregation propensities

Proceedings of the National Academy of Sciences - PNAS, 2020-08, Vol.117 (33), p.19926-19937

2020

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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (26), p.9384-9389

2014

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Exploring the aggregation free energy landscape of the amyloid-β protein (1–40)

Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (42), p.11835-11840

2016

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Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

Science (American Association for the Advancement of Science), 2011-12, Vol.334 (6060), p.1241-1245

2011

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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

The Journal of cell biology, 2015-05, Vol.209 (3), p.419-433

2015

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Molecular basis for amyloid-β polymorphism

Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (41), p.16938-16943

2011

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Demonstration of catch bonds between an integrin and its ligand

The Journal of cell biology, 2009-06, Vol.185 (7), p.1275-1284

2009

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Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (35), p.15595-15600

2010

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The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

Science (American Association for the Advancement of Science), 2012-06, Vol.336 (6085), p.1168-1171

2012

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Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.4033-4038

2013

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SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins

Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (46), p.23040-23049

2019

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Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (48), p.12731-12736

2017

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Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

Science (American Association for the Advancement of Science), 2021-04, Vol.372 (6541)

2021

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Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (5)

2022

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Spatiotemporal Monitoring of Pseudomonas syringae Effectors via Type III Secretion Using Split Fluorescent Protein Fragments

The Plant cell, 2017-07, Vol.29 (7), p.1571-1584

2017

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Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (35), p.E5212-E5221

2016

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Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (8), p.2798

2013

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Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1

Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (6), p.1988-1993

2006

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Ligand deconstruction: Why some fragment binding positions are conserved and others are not

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (20), p.E2585-E2594

2015

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Activation and intrinsic γ-secretase activity of presenilin 1

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (50), p.21435-21440

2010

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N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.E1839-E1847

2012

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Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

The Journal of cell biology, 2007-08, Vol.178 (5), p.757-764

2007

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Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL

Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (51), p.E11924-E11932

2018

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Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

On the role of sidechain size and charge in the aggregation of A β 42 with familial mutations

Differences in the free energies between the excited states of A β 40 and A β 42 monomers encode their aggregation propensities

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

Exploring the aggregation free energy landscape of the amyloid-β protein (1–40)

Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

Molecular basis for amyloid-β polymorphism

Demonstration of catch bonds between an integrin and its ligand

Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression

SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

Spatiotemporal Monitoring of Pseudomonas syringae Effectors via Type III Secretion Using Split Fluorescent Protein Fragments

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila

Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy

Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1

Ligand deconstruction: Why some fragment binding positions are conserved and others are not

Activation and intrinsic γ-secretase activity of presenilin 1

N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL

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