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PI3K inhibitors in inflammation, autoimmunity and cancer

Current opinion in pharmacology, 2015-08, Vol.23, p.82-91

2015

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Histamine-secreting microbes are increased in the gut of adult asthma patients

Journal of allergy and clinical immunology, 2016-11, Vol.138 (5), p.1491-1494.e7

2016

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IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

EMBO molecular medicine, 2016-09, Vol.8 (9), p.1099-1112

2016

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Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

American journal of respiratory and critical care medicine, 2016-10, Vol.194 (8), p.961-973

2016

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Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

Pharmaceutical research, 2016-11, Vol.33 (11), p.2604-2616

2016

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A conserved coiled‐coil protein pair focuses the cytokinetic Z‐ring in Caulobacter crescentus

Molecular microbiology, 2017-09, Vol.105 (5), p.721-740

2017

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Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

Immunity (Cambridge, Mass.), 2001-10, Vol.15 (4), p.533-543

2001

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Young adults' perceptions of technology use with extended family

Family relations, 2023-04, Vol.72 (2), p.565-584

2023

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Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases

Annals of the New York Academy of Sciences, 2013-03, Vol.1280 (1), p.35-39

2013

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Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

The Journal of experimental medicine, 2005-12, Vol.202 (11), p.1563-1573

2005

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A Restricted Subset of Dendritic Cells Captures Airborne Antigens and Remains Able to Activate Specific T Cells Long after Antigen Exposure

Immunity (Cambridge, Mass.), 2002-02, Vol.16 (2), p.271-283

2002

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Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

Human reproduction (Oxford), 2016-08, Vol.31 (8), p.1738-1748

2016

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Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

The Journal of cell biology, 2017-04, Vol.216 (4), p.1123-1141

2017

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Altered fatty acid metabolism and reduced stearoyl‐coenzyme a desaturase activity in asthma

Allergy (Copenhagen), 2017-11, Vol.72 (11), p.1744-1752

2017

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Nonhuman primate models of asthma

The Journal of experimental medicine, 2005-06, Vol.201 (12), p.1875-1879

2005

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A novel cell-processing method ‘AgarCytos’ in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Human reproduction (Oxford), 2013-10, Vol.28 (10), p.2608-2620

2013

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In situ targeted base editing of bacteria in the mouse gut

Nature (London), 2024-08, Vol.632 (8026), p.877-884

2024

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The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport

American journal of respiratory cell and molecular biology, 2024-09, Vol.71 (3), p.282-293

2024

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Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures

American journal of respiratory cell and molecular biology, 2021-11, Vol.65 (5), p.544-554

2021

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Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption

Clinical pharmacokinetics, 2022-02, Vol.61 (2), p.281-293

2022

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Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

Thorax, 2019-07, Vol.74 (7), p.659-666

2019

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Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression

Clinical and experimental allergy, 2010-07, Vol.40 (7), p.1025-1035

2010

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Lung inflammation and epithelial changes in a murine model of atopic asthma

American journal of respiratory cell and molecular biology, 1996-05, Vol.14 (5), p.425-438

1996

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An investigation of the anti-inflammatory effects and a potential biomarker of PI3K[delta] inhibition in COPD T cells

Clinical and experimental pharmacology & physiology, 2017-09, Vol.44 (9), p.932

2017

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First‐in‐Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well‐Tolerated

Clinical pharmacology and therapeutics, 2018-08, Vol.104 (2), p.335-345

2018

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PI3K inhibitors in inflammation, autoimmunity and cancer

Histamine-secreting microbes are increased in the gut of adult asthma patients

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

A conserved coiled‐coil protein pair focuses the cytokinetic Z‐ring in Caulobacter crescentus

Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

Young adults' perceptions of technology use with extended family

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

A Restricted Subset of Dendritic Cells Captures Airborne Antigens and Remains Able to Activate Specific T Cells Long after Antigen Exposure

Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

Altered fatty acid metabolism and reduced stearoyl‐coenzyme a desaturase activity in asthma

Nonhuman primate models of asthma

A novel cell-processing method ‘AgarCytos’ in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

In situ targeted base editing of bacteria in the mouse gut

The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport

Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption

Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression

Lung inflammation and epithelial changes in a murine model of atopic asthma

An investigation of the anti-inflammatory effects and a potential biomarker of PI3K[delta] inhibition in COPD T cells

First‐in‐Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well‐Tolerated

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