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Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation

Bioorganic & medicinal chemistry, 2015-12, Vol.23 (24), p.7585-7596

2015

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Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1270-1274

2011

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SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads

Bioorganic & medicinal chemistry letters, 2023-11, Vol.96, p.129489-129489, Article 129489

2023

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Novel M 4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (3), p.362

2019

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CNS delivery of targeted protein degraders

Journal of controlled release, 2024-08, Vol.372, p.661-673

2024

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Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

Bioorganic & medicinal chemistry, 2017-11, Vol.25 (22), p.6149-6166

2017

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Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles

Journal of controlled release, 2014-09, Vol.190, p.531-541

2014

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Bioprospecting for Antibacterial Drugs: a Multidisciplinary Perspective on Natural Product Source Material, Bioassay Selection and Avoidable Pitfalls

Pharmaceutical research, 2020-07, Vol.37 (7), p.125-125, Article 125

2020

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Exploiting the cancer niche: Tumor-associated macrophages and hypoxia as promising synergistic targets for nano-based therapy

Journal of controlled release, 2017-05, Vol.253, p.82-96

2017

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Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective

Bioorganic & medicinal chemistry letters, 2022-05, Vol.63, p.128653-128653, Article 128653

2022

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Remodeling the hepatic immune microenvironment and demolishing T cell traps to enhance immunotherapy efficacy in liver metastasis

Journal of controlled release, 2024-09, Vol.373, p.890-904

2024

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Let’s get biophysical – How to get your favorite protein’s digits

Bioorganic & medicinal chemistry, 2024-10, Vol.112, p.117873, Article 117873

2024

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Partial protein binding of uracil and thymine affects accurate dihydropyrimidine dehydrogenase (DPD) phenotyping

Journal of pharmaceutical and biomedical analysis, 2024-10, Vol.249, p.116381, Article 116381

2024

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Suspect screening and untargeted analysis of veterinary drugs in food by LC-HRMS: Application of background exclusion-dependent acquisition for retrospective analysis of unknown xenobiotics

Journal of pharmaceutical and biomedical analysis, 2022-02, Vol.210, p.114583-114583, Article 114583

2022

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Challenges in evaluation of chitosan and trimethylated chitosan (TMC) as mucosal permeation enhancers: From synthesis to in vitro application

Journal of controlled release, 2014-01, Vol.173, p.18-31

2014

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Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research

Pharmaceutical research, 2010-06, Vol.27 (6), p.1027-1041

2010

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Development and validation of an LC–MS/MS method to measure the BRAF inhibitors dabrafenib and encorafenib quantitatively and four major metabolites semi-quantitatively in human plasma

Journal of pharmaceutical and biomedical analysis, 2023-09, Vol.234, p.115594-115594, Article 115594

2023

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Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages

Journal of controlled release, 2016-02, Vol.224, p.103-111

2016

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Butenolides from a marine-derived fungus Aspergillus terreus with antitumor activities against pancreatic ductal adenocarcinoma cells

Bioorganic & medicinal chemistry, 2018-12, Vol.26 (22), p.5903-5910

2018

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Ruthenium complexes as anticancer agents

Current medicinal chemistry, 2006-04, Vol.13 (9), p.1085-1107

Kostova, Irena

2006

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Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

Journal of controlled release, 2012-05, Vol.160 (1), p.72-80

2012

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Double the Chemistry, Double the Fun: Structural Diversity and Biological Activity of Marine-Derived Diketopiperazine Dimers

Marine drugs, 2019-09, Vol.17 (10), p.551

2019

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Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks

Journal of controlled release, 2018-12, Vol.292, p.221-234

2018

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Ultra-fast quantitation of voriconazole in human plasma by coated blade spray mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2017-09, Vol.144, p.106-111

2017

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High-Throughput Sequencing Technology Assisted Investigation of the Correlation Between Intestinal Flora, Serum Biochemistry, Blood Lipids, and Tumour Markers in Patients with Gastric Cancer and Healthy Plateau Residents

Combinatorial chemistry & high throughput screening, 2024-01, Vol.27 (7), p.996-1010

2024

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Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads

Novel M 4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

CNS delivery of targeted protein degraders

Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles

Bioprospecting for Antibacterial Drugs: a Multidisciplinary Perspective on Natural Product Source Material, Bioassay Selection and Avoidable Pitfalls

Exploiting the cancer niche: Tumor-associated macrophages and hypoxia as promising synergistic targets for nano-based therapy

Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective

Remodeling the hepatic immune microenvironment and demolishing T cell traps to enhance immunotherapy efficacy in liver metastasis

Let’s get biophysical – How to get your favorite protein’s digits

Partial protein binding of uracil and thymine affects accurate dihydropyrimidine dehydrogenase (DPD) phenotyping

Suspect screening and untargeted analysis of veterinary drugs in food by LC-HRMS: Application of background exclusion-dependent acquisition for retrospective analysis of unknown xenobiotics

Challenges in evaluation of chitosan and trimethylated chitosan (TMC) as mucosal permeation enhancers: From synthesis to in vitro application

Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research

Development and validation of an LC–MS/MS method to measure the BRAF inhibitors dabrafenib and encorafenib quantitatively and four major metabolites semi-quantitatively in human plasma

Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages

Butenolides from a marine-derived fungus Aspergillus terreus with antitumor activities against pancreatic ductal adenocarcinoma cells

Ruthenium complexes as anticancer agents

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

Double the Chemistry, Double the Fun: Structural Diversity and Biological Activity of Marine-Derived Diketopiperazine Dimers

Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks

Ultra-fast quantitation of voriconazole in human plasma by coated blade spray mass spectrometry

High-Throughput Sequencing Technology Assisted Investigation of the Correlation Between Intestinal Flora, Serum Biochemistry, Blood Lipids, and Tumour Markers in Patients with Gastric Cancer and Healthy Plateau Residents

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