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The Titration Paradox Turns Pharmacology Upside Down

Clinical pharmacology and therapeutics, 2021-08, Vol.110 (2), p.292-293

2021

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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Journal for immunotherapy of cancer, 2018-02, Vol.6 (1), p.17-15, Article 17

2018

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Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Microbiology spectrum, 2022-04, Vol.10 (2), p.e0216721

2022

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Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

Respiratory research, 2011-04, Vol.12 (53), p.54-54, Article 54

2011

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Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

Physiological reports, 2018-03, Vol.6 (5), p.e13614-n/a

2018

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Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Anesthesiology (Philadelphia), 2002-10, Vol.97 (4), p.827-836

2002

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Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Anesthesiology (Philadelphia), 2001, Vol.94 (1), p.63-73

2001

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Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development

Journal of clinical pharmacology, 2000-12, Vol.40 (12), p.1399-1418

2000

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Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development

Journal of clinical pharmacology, 2010-09, Vol.50 (S9), p.146S-150S

2010

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Innovative approaches to clinical development and trial design

Annali dell'Istituto superiore di sanità, 2011, Vol.47 (1), p.8-13

2011

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Communicating With the FDA: The "Third Rail" of a New Model for Drug Development

Journal of clinical pharmacology, 2008-02, Vol.48 (2), p.144-145

2008

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Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

Anesthesiology (Philadelphia), 2000-02, Vol.92 (2), p.312-324

2000

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A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

Clinical pharmacology and therapeutics, 1997-01, Vol.61 (1), p.45-58

1997

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The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Anesthesiology (Philadelphia), 1993-11, Vol.79 (5), p.881-892

1993

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Enriched analgesic efficacy studies: An assessment by clinical trial simulation

Contemporary clinical trials, 2006-04, Vol.27 (2), p.165-173

2006

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Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

British journal of clinical pharmacology, 1996-12, Vol.42 (6), p.747-756

1996

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Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S39-S46

2017

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Exposure‐Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

Journal of clinical pharmacology, 2017-05, Vol.57 (5), p.573-583

2017

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Survival prediction using time-evolving tumor load: An approach to rationally design treatment sequencing, staging, and dosing strategies for oncology combinations

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e20040-e20040

2017

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The future of drug development: advancing clinical trial design

Nature reviews. Drug discovery, 2009-12, Vol.8 (12), p.949-957

2009

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Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development

Journal of pharmacokinetics and pharmacodynamics, 2005-04, Vol.32 (2), p.199-211

2005

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Inadequate anaesthesia in lethal injection for execution

The Lancet (British edition), 2005-09, Vol.366 (9491), p.1073-1073

Groner, Jonathan I

2005

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Dynamic predictions of patient survival using longitudinal tumor size in non-small cell lung cancer: Approach towards personalized medicine

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e20606-e20606

2017

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Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam

Clinical pharmacology and therapeutics, 1990-11, Vol.48 (5), p.555-567

1990

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Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

Journal of pharmacokinetics and pharmacodynamics, 2010-12, Vol.37 (6), p.629-644

2010

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The Titration Paradox Turns Pharmacology Upside Down

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development

Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development

Innovative approaches to clinical development and trial design

Communicating With the FDA: The "Third Rail" of a New Model for Drug Development

Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Enriched analgesic efficacy studies: An assessment by clinical trial simulation

Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet

Exposure‐Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

Survival prediction using time-evolving tumor load: An approach to rationally design treatment sequencing, staging, and dosing strategies for oncology combinations

The future of drug development: advancing clinical trial design

Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development

Inadequate anaesthesia in lethal injection for execution

Dynamic predictions of patient survival using longitudinal tumor size in non-small cell lung cancer: Approach towards personalized medicine

Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam

Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

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