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Medicinal chemistry of adenosine, P2Y and P2X receptors

Neuropharmacology, 2016-05, Vol.104, p.31-49

2016

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The P2X7 receptor: A main player in inflammation

Biochemical pharmacology, 2018-05, Vol.151, p.234-244

2018

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The therapeutic potential of purinergic signalling

Biochemical pharmacology, 2018-05, Vol.151, p.157-165

Burnstock, Geoffrey

2018

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P2X receptors as drug targets

Molecular pharmacology, 2013-04, Vol.83 (4), p.759-769

2013

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P2X and P2Y receptors—role in the pathophysiology of the nervous system

International Journal of Molecular Sciences, 2014-12, Vol.15 (12), p.23672-23704

2014

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Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists

Current medicinal chemistry, 2015-01, Vol.22 (7), p.915-928

2015

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Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets

Biochemical pharmacology, 2021-05, Vol.187, p.114311-114311, Article 114311

2021

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The evolution of P2X7 antagonists with a focus on CNS indications

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (16), p.3838-3845

2016

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Identification of second-generation P2X3 antagonists for treatment of pain

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1392-1396

2018

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Single‐ and Multiple‐Dose Pharmacokinetics of Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, in Healthy Adults

Journal of clinical pharmacology, 2024-08, Vol.64 (8), p.1023-1029

2024

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Agonists and Antagonists for Purinergic Receptors

Methods in molecular biology (Clifton, N.J.), 2020-01, Vol.2041, p.45

2020

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P2X3 Receptor Antagonist Eliapixant in Phase I Clinical Trials: Safety and Inter-ethnic Comparison of Pharmacokinetics in Healthy Chinese and Japanese Participants

Clinical pharmacokinetics, 2024-06, Vol.63 (6), p.901-915

2024

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P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice

Biochemical pharmacology, 2020-10, Vol.180, p.114199-114199, Article 114199

2020

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Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis

Current medicinal chemistry, 2015-01, Vol.22 (7), p.799-818

2015

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P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain

Neurotherapeutics, 2020-07, Vol.17 (3), p.826-838

Krajewski, Jeffrey L.

2020

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Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3157-3163

2015

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P2 receptors, platelet function and pharmacological implications

Thrombosis and haemostasis, 2008-03, Vol.99 (3), p.466-472

Gachet, Christian

2008

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TMEM163 Regulates ATP-Gated P2X Receptor and Behavior

Cell reports (Cambridge), 2020-06, Vol.31 (9), p.107704-107704, Article 107704

2020

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Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

Journal of rheumatology, 2012-04, Vol.39 (4), p.720

2012

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Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

Annals of the rheumatic diseases, 2012-10, Vol.71 (10), p.1630-1635

2012

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Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

British journal of pharmacology, 2021-02, Vol.178 (3), p.489-514

2021

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ATP-gated P2X cation-channels

Neuropharmacology, 2009-01, Vol.56 (1), p.208-215

2009

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Purinergic signaling in diabetes and metabolism

Biochemical pharmacology, 2021-05, Vol.187, p.114393-114393, Article 114393

2021

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Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.759-763

2017

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The role of P2X4 receptors in chronic pain: A potential pharmacological target

Biomedicine & pharmacotherapy, 2020-09, Vol.129, p.110447-110447, Article 110447

2020

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Medicinal chemistry of adenosine, P2Y and P2X receptors

The P2X7 receptor: A main player in inflammation

The therapeutic potential of purinergic signalling

P2X receptors as drug targets

P2X and P2Y receptors—role in the pathophysiology of the nervous system

Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists

Medicinal chemistry of P2 and adenosine receptors: Common scaffolds adapted for multiple targets

The evolution of P2X7 antagonists with a focus on CNS indications

Identification of second-generation P2X3 antagonists for treatment of pain

Single‐ and Multiple‐Dose Pharmacokinetics of Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, in Healthy Adults

Agonists and Antagonists for Purinergic Receptors

P2X3 Receptor Antagonist Eliapixant in Phase I Clinical Trials: Safety and Inter-ethnic Comparison of Pharmacokinetics in Healthy Chinese and Japanese Participants

P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice

Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis

P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

P2 receptors, platelet function and pharmacological implications

TMEM163 Regulates ATP-Gated P2X Receptor and Behavior

Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

ATP-gated P2X cation-channels

Purinergic signaling in diabetes and metabolism

Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles

The role of P2X4 receptors in chronic pain: A potential pharmacological target

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