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How we manage patients with pyruvate kinase deficiency

British journal of haematology, 2019-03, Vol.184 (5), p.721-734

2019

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Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

The New England journal of medicine, 2019-09, Vol.381 (10), p.933-944

2019

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Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients

Haematologica (Roma), 2020-11, Vol.105 (11), p.2651-2654

2020

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The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Current cancer drug targets, 2008-02, Vol.8 (1), p.7

2008

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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

Journal of medicinal chemistry, 2023-01, Vol.66 (2), p.1157-1171

2023

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Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision

PloS one, 2021-09, Vol.16 (9), p.e0257560-e0257560

2021

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Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Current topics in medicinal chemistry, 2007-07, Vol.7 (14), p.1349

2007

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Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2087-2093

2017

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The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design

BMJ open, 2023-03, Vol.13 (3), p.e063605-e063605

2023

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Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3935-3958

2024

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Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis

PLoS neglected tropical diseases, 2023-10, Vol.17 (10), p.e0011652-e0011652

2023

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Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

Channels (Austin, Tex.), 2022-12, Vol.16 (1), p.230-243

2022

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Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

PLoS medicine, 2006-07, Vol.3 (7), p.e290

2006

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Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study

Frontiers in physiology, 2022-05, Vol.13, p.865391-865391

2022

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Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2683-2688

2017

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Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists

Current topics in medicinal chemistry, 2006-04, Vol.6 (7), p.697

2006

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Quantification of Silent Cerebral Infarction on High-Resolution FLAIR and Cognition in Sickle Cell Anemia

Frontiers in neurology, 2022-06, Vol.13, p.867329-867329

2022

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Putting unstable hemoglobins on the map of London

American journal of hematology, 2023-09, Vol.98 (9), p.1488-1489

2023

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Biomimetic Synthesis of (−)-Longithorone A

Journal of the American Chemical Society, 2002-02, Vol.124 (5), p.773-775

2002

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Voxelotor in sickle cell disease

American journal of hematology, 2022-06, Vol.97 (6), p.830-832

2022

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A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Blood, 2019-04, Vol.133 (17), p.1865-1875

2019

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Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

ACS medicinal chemistry letters, 2021-06, Vol.12 (6), p.1038-1049

2021

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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study

The Lancet (British edition), 2022-08, Vol.400 (10351), p.493-501

2022

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Discovery of Arylsulfonamide Na v 1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

ACS medicinal chemistry letters, 2021-06, Vol.12 (6), p.1038-1049

2021

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Peripheral blood features of iron overload in post‐splenectomy, type I congenital dyserythropoietic anemia

American journal of hematology, 2022-02, Vol.97 (2), p.237-238

2022

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How we manage patients with pyruvate kinase deficiency

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients

The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision

Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design

Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic

Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study

Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model

Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists

Quantification of Silent Cerebral Infarction on High-Resolution FLAIR and Cognition in Sickle Cell Anemia

Putting unstable hemoglobins on the map of London

Biomimetic Synthesis of (−)-Longithorone A

Voxelotor in sickle cell disease

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study

Discovery of Arylsulfonamide Na v 1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

Peripheral blood features of iron overload in post‐splenectomy, type I congenital dyserythropoietic anemia

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