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Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

Journal of medicinal chemistry, 1997-10, Vol.40 (22), p.3601-3616

1997

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Integration of ADAS Into One Central Platform Controller

Auto Tech Review, 2016, Vol.5 (7), p.32-35

Lang, Marc

2016

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Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805

Molecular cancer therapeutics, 2010-07, Vol.9 (7), p.1945-1955

2010

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Abstract 140: Discovery and biological evaluation of PQR530, a highly potent dual pan-PI3K/mTORC1/2 inhibitor

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.140-140

2017

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A generic remote sensing approach to derive operational essential biodiversity variables (EBVs) for conservation planning

Methods in ecology and evolution, 2018-08, Vol.9 (8), p.1822-1836

2018

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Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1336-1336

2016

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Abstract 159: Pharmacological characterization of the selective, orally bioavailable, potent dual PI3K/mTORC1/2 inhibitor PQR530

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.159-159

2017

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Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Molecular cancer therapeutics, 2016-10, Vol.15 (10), p.2334-2343

2016

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Abstract 393A: Pharmacological characterization of the selective, orally bioavailable, potent mTORC1/2 inhibitor PQR620

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.393-393A

2016

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Abstract 4514: PQR309: A potent, brain-penetrant, dual pan-PI3K/mTOR inhibitor with excellent oral bioavailability and tolerability

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4514-4514

2015

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Abstract DDT01-01: Discovery of CGM097 as a novel Mdm2 inhibitor

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.DDT01-01-DDT01-01

2014

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Abstract 2664: PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2664-2664

2015

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Abstract 1797: Discovery of NVP-CGM097, a highly potent and optimized small molecule inhibitor of Mdm2 under evaluation in a Phase I clinical trial

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1797-1797

2014

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New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2310-2323

2000

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Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.1922-1922

2012

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Entry into a New Class of Potent Proteasome Inhibitors Having High Antiproliferative Activity by Structure-Based Design

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4810-4813

2004

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High Degree of Integration of ADAS Functions into One Central Platform Controller

ATZelektronik worldwide, 2015-08, Vol.10 (4), p.40-43

Lang, Marc

2015

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New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3387-3401

1998

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Why Trust Science?

Oreskes, Naomi

2021

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Novel, Potent and Selective JAK2 Inhibitors

Blood, 2009-11, Vol.114 (22), p.3777-3777

2009

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Mehr Sicherheit im Straßenverkehr: Fahrerassistenzsystem in Straßenbahnen warnt vor Kollisionen

V+T Verkehr und Technik, 2015-09 (9), Article 7

2015

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Transgenerational Inheritance and Resetting of Stress, Induced Loss of Epigenetic Gene Silencing in Arabidopsis

Molecular plant, 2010-05, Vol.3 (3), p.594-602

2010

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Usefulness of Antiplatelet Drugs in the Management of Heparin-Associated Thrombocytopenia and Thrombosis

Annals of vascular surgery, 1991-11, Vol.5 (6), p.552-555

1991

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Aza-Peptide Analogs as Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors with Oral Bioavailability

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3203-3216

1996

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Structure-Based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-Like activity of the human 20 S proteasome

Bioorganic & medicinal chemistry letters, 2002, Vol.12 (10), p.1331-1334

2002

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Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

Integration of ADAS Into One Central Platform Controller

Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805

Abstract 140: Discovery and biological evaluation of PQR530, a highly potent dual pan-PI3K/mTORC1/2 inhibitor

A generic remote sensing approach to derive operational essential biodiversity variables (EBVs) for conservation planning

Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor

Abstract 159: Pharmacological characterization of the selective, orally bioavailable, potent dual PI3K/mTORC1/2 inhibitor PQR530

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Abstract 393A: Pharmacological characterization of the selective, orally bioavailable, potent mTORC1/2 inhibitor PQR620

Abstract 4514: PQR309: A potent, brain-penetrant, dual pan-PI3K/mTOR inhibitor with excellent oral bioavailability and tolerability

Abstract DDT01-01: Discovery of CGM097 as a novel Mdm2 inhibitor

Abstract 2664: PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor

Abstract 1797: Discovery of NVP-CGM097, a highly potent and optimized small molecule inhibitor of Mdm2 under evaluation in a Phase I clinical trial

New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis

Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity

Entry into a New Class of Potent Proteasome Inhibitors Having High Antiproliferative Activity by Structure-Based Design

High Degree of Integration of ADAS Functions into One Central Platform Controller

New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development

Why Trust Science?

Novel, Potent and Selective JAK2 Inhibitors

Mehr Sicherheit im Straßenverkehr: Fahrerassistenzsystem in Straßenbahnen warnt vor Kollisionen

Transgenerational Inheritance and Resetting of Stress, Induced Loss of Epigenetic Gene Silencing in Arabidopsis

Usefulness of Antiplatelet Drugs in the Management of Heparin-Associated Thrombocytopenia and Thrombosis

Aza-Peptide Analogs as Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors with Oral Bioavailability

Structure-Based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-Like activity of the human 20 S proteasome

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