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Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Nature cell biology, 2020-04, Vol.22 (4), p.389-400

2020

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Efficacy of MEK inhibition in patients with histiocytic neoplasms

Nature (London), 2019-03, Vol.567 (7749), p.521-524

2019

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Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling

Cancer research (Chicago, Ill.), 2018-06, Vol.78 (11), p.3041-3053

2018

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

Cancer cell, 2020-06, Vol.37 (6), p.834-849.e13

2020

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Nature genetics, 2012-02, Vol.44 (2), p.133-139

2012

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VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17

BMC biology, 2024-10, Vol.22 (1), p.222-24, Article 222

2024

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Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

Oncogene, 2019-06, Vol.38 (25), p.5076-5090

2019

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Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

Circulation (New York, N.Y.), 2019-07, Vol.140 (3), p.207-224

2019

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c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

Cancer cell, 2011-05, Vol.19 (5), p.652-663

2011

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Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212

Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.720-729

2012

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Pharmacoproteomic characterisation of human colon and rectal cancer

Molecular systems biology, 2017-11, Vol.13 (11), p.951-n/a

2017

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Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

European journal of cancer (1990), 2013-12, Vol.49 (18), p.3936-3944

2013

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ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

Biochemical and biophysical research communications, 2018-06, Vol.500 (4), p.873-878

2018

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The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

The Journal of biological chemistry, 2017-05, Vol.292 (21), p.8750-8761

2017

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Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

Science signaling, 2011-03, Vol.4 (166), p.ra17

2011

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KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

Molecular cancer therapeutics, 2009-04, Vol.8 (4), p.834-843

2009

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RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation

Plant physiology (Bethesda), 2020-05, Vol.183 (1), p.331-344

2020

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Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis

Oncogene, 2012-08, Vol.31 (34), p.3889-3900

2012

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Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation

PloS one, 2014-09, Vol.9 (9), p.e106725-e106725

2014

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Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

The Journal of biological chemistry, 2014-12, Vol.289 (49), p.34366-34377

2014

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Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

The Journal of biological chemistry, 2013-11, Vol.288 (47), p.33966-33977

2013

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MEK Is a Key Regulator of Gliogenesis in the Developing Brain

Neuron (Cambridge, Mass.), 2012-09, Vol.75 (6), p.1035-1050

2012

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The expression of ERK and JNK in patients with an endemic osteochondropathy, Kashin-Beck disease

Experimental cell research, 2017-10, Vol.359 (2), p.337-341

2017

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Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues

Molecular and cellular endocrinology, 2015-03, Vol.403, p.64-77

2015

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Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling

Efficacy of MEK inhibition in patients with histiocytic neoplasms

Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling

SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212

Pharmacoproteomic characterisation of human colon and rectal cancer

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer

The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation

Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis

Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation

Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

MEK Is a Key Regulator of Gliogenesis in the Developing Brain

The expression of ERK and JNK in patients with an endemic osteochondropathy, Kashin-Beck disease

Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues

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