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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

EMBO molecular medicine, 2017-09, Vol.9 (9), p.1183-1197

2017

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In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

EMBO molecular medicine, 2018-11, Vol.10 (11), p.n/a

2018

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Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Molecular therapy. Methods & clinical development, 2019-03, Vol.12, p.19-31

2019

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Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

PLoS pathogens, 2016-06, Vol.12 (6), p.e1005641-e1005641

2016

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Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

EMBO molecular medicine, 2024-04, Vol.16 (4), p.784-804

2024

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Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Molecular therapy, 2013-01, Vol.21 (1), p.109-118

2013

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Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

Molecular therapy, 2022-07, Vol.30 (7), p.2401-2415

2022

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A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Frontiers in immunology, 2017-06, Vol.8, p.676-676

2017

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CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

Frontiers in immunology, 2023-08, Vol.14, p.1183698-1183698

2023

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DARPins: An Efficient Targeting Domain for Lentiviral Vectors

Molecular therapy, 2011-04, Vol.19 (4), p.686-693

2011

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In vivo generation of CAR T cells in the presence of human myeloid cells

Molecular therapy. Methods & clinical development, 2022-09, Vol.26, p.144-156

2022

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APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Frontiers in cellular neuroscience, 2023-01, Vol.17, p.1106176-1106176

2023

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CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

PloS one, 2013-11, Vol.8 (11), p.e79047-e79047

2013

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Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

Molecular therapy. Methods & clinical development, 2023-03, Vol.28, p.90-98

2023

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Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo

PloS one, 2014-07, Vol.9 (7), p.e101644-e101644

2014

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Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.359-369

2021

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Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.334-347

2021

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Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Trends in biotechnology (Regular ed.), 2015-12, Vol.33 (12), p.777-790

2015

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Virotherapy Research in Germany: From Engineering to Translation

Human gene therapy, 2017-10, Vol.28 (10), p.800

2017

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Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

iScience, 2021-03, Vol.24 (3), p.102170-102170, Article 102170

2021

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Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

PloS one, 2012-10, Vol.7 (10), p.e46667-e46667

2012

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CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Advanced science, 2023-12, Vol.10 (35), p.e2302992-n/a

2023

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Chimäre Antigenrezeptoren (CARs) in der Onkologie: eine Übersicht zu klinischer Anwendung und neuen Entwicklungen

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2020, Vol.63 (11), p.1331-1340

2020

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Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells

PloS one, 2014-12, Vol.9 (12), p.e116114-e116114

2014

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Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv

Protein engineering, design and selection, 2015-04, Vol.28 (4), p.93-106

2015

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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

DARPins: An Efficient Targeting Domain for Lentiviral Vectors

In vivo generation of CAR T cells in the presence of human myeloid cells

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo

Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Virotherapy Research in Germany: From Engineering to Translation

Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Chimäre Antigenrezeptoren (CARs) in der Onkologie: eine Übersicht zu klinischer Anwendung und neuen Entwicklungen

Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells

Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv

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