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Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution

Human gene therapy, 2017-11, Vol.28 (11), p.1075

2017

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Adeno-Associated Viruses (AAV) and Host Immunity - A Race Between the Hare and the Hedgehog

Frontiers in immunology, 2021-10, Vol.12, p.753467-753467

2021

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CRISPR genome engineering and viral gene delivery: A case of mutual attraction

Biotechnology journal, 2015-02, Vol.10 (2), p.258-272

2015

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The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression

Silence, 2011-10, Vol.2 (1), p.8-8

Grimm, Dirk

2011

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Next-generation AAV vectors for clinical use: an ever-accelerating race

Virus genes, 2017-10, Vol.53 (5), p.707-713

2017

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All for One, One for All: New Combinatorial RNAi Therapies Combat Hepatitis C Virus Evolution

Molecular therapy, 2012-09, Vol.20 (9), p.1661-1663

Grimm, Dirk

2012

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Methane formation driven by reactive oxygen species across all living organisms

Nature (London), 2022-03, Vol.603 (7901), p.482-487

2022

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Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

The Journal of clinical investigation, 2011-12, Vol.121 (12), p.4850-4860

2011

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Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Nature communications, 2020-10, Vol.11 (1), p.5432-5432, Article 5432

2020

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Every little bit helps: A single-residue switch in a vascular AAV enables blood-brain barrier penetration

Molecular therapy. Methods & clinical development, 2023-06, Vol.29, p.364-365

2023

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Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins

Nucleic acids research, 2019-07, Vol.47 (13), p.e75

2019

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Fantastic AAV Gene Therapy Vectors and How to Find Them—Random Diversification, Rational Design and Machine Learning

Pathogens (Basel), 2022-07, Vol.11 (7), p.756

2022

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CRISPR/Cas9-mediated genome engineering: An adeno-associated viral (AAV) vector toolbox

Biotechnology journal, 2014-11, Vol.9 (11), p.1402-1412

2014

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Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR-Cas gene editing

Signal transduction and targeted therapy, 2021-05, Vol.6 (1), p.206-206, Article 206

2021

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Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

Gastroenterology (New York, N.Y. 1943), 2020-05, Vol.158 (6), p.1762-1775.e9

2020

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Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

Hepatology (Baltimore, Md.), 2017-09, Vol.66 (3), p.703-716

2017

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Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (30), p.E4007-E4016

2015

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Nature, 2006-05, Vol.441 (7092), p.537-541

2006

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Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9

Nature communications, 2023-09, Vol.14 (1), p.6116-6116, Article 6116

2023

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In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

Journal of Virology, 2008-06, Vol.82 (12), p.5887-5911

2008

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Next-generation AAV vectors—do not judge a virus (only) by its cover

Human molecular genetics, 2019-10, Vol.28 (R1), p.R3-R14

2019

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Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Nature communications, 2021-11, Vol.12 (1), p.6769-6769, Article 6769

2021

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Right on target: The next class of efficient, safe, and specific RNAi triggers

Molecular therapy. Nucleic acids, 2022-06, Vol.28, p.363-365

2022

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Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Nucleic acids research, 2021-03, Vol.49 (5), p.e29

2021

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Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions

PLoS neglected tropical diseases, 2022-10, Vol.16 (10), p.e0010876-e0010876

2022

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Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution

Adeno-Associated Viruses (AAV) and Host Immunity - A Race Between the Hare and the Hedgehog

CRISPR genome engineering and viral gene delivery: A case of mutual attraction

The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression

Next-generation AAV vectors for clinical use: an ever-accelerating race

All for One, One for All: New Combinatorial RNAi Therapies Combat Hepatitis C Virus Evolution

Methane formation driven by reactive oxygen species across all living organisms

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Every little bit helps: A single-residue switch in a vascular AAV enables blood-brain barrier penetration

Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins

Fantastic AAV Gene Therapy Vectors and How to Find Them—Random Diversification, Rational Design and Machine Learning

CRISPR/Cas9-mediated genome engineering: An adeno-associated viral (AAV) vector toolbox

Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR-Cas gene editing

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

Next-generation AAV vectors—do not judge a virus (only) by its cover

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Right on target: The next class of efficient, safe, and specific RNAi triggers

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions

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