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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

Nature chemical biology, 2015-09, Vol.11 (9), p.705-712

2015

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Automated structure prediction of trans-acyltransferase polyketide synthase products

Nature chemical biology, 2019-08, Vol.15 (8), p.813-821

2019

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Structure and Mechanisms of Assembly-Line Polyketide Synthases

Annual review of biochemistry, 2024-08, Vol.93 (1), p.471-498

2024

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Aromatic Polyketides from a Symbiotic Strain Aspergillus fumigatus D and Characterization of Their Biosynthetic Gene D8.t287

Marine drugs, 2020-06, Vol.18 (6), p.324

2020

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Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis

Nature chemistry, 2020-08, Vol.12 (8), p.755-763

2020

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Polyketide reductases in defense‐related parasorboside biosynthesis in Gerbera hybrida share processing strategies with microbial polyketide synthase systems

The New phytologist, 2022-10, Vol.236 (1), p.296-308

2022

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Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl‐Substituted Aromatic Polyketides

Angewandte Chemie International Edition, 2023-01, Vol.62 (5), p.e202214026-n/a

International ed. in English, 2023

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Assessing and harnessing updated polyketide synthase modules through combinatorial engineering

Nature communications, 2024-08, Vol.15 (1), p.6485-12, Article 6485

2024

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Lugdunomycin, an Angucycline‐Derived Molecule with Unprecedented Chemical Architecture

Angewandte Chemie International Edition, 2019-02, Vol.58 (9), p.2809-2814

International ed. in English, 2019

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Animal biosynthesis of complex polyketides in a photosynthetic partnership

Nature communications, 2020-06, Vol.11 (1), p.2882-2882, Article 2882

2020

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Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2

Natural product reports, 2024-08, Vol.41 (8), p.1219-1234

2024

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Toblerols: Cyclopropanol‐Containing Polyketide Modulators of Antibiosis in Methylobacteria

Angewandte Chemie International Edition, 2018-01, Vol.57 (4), p.977-981

International ed. in English, 2018

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Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

Science (American Association for the Advancement of Science), 2013-09, Vol.341 (6150), p.1089-1094

2013

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Insights into modular polyketide synthase loops aided by repetitive sequences

Proteins, structure, function, and bioinformatics, 2021-09, Vol.89 (9), p.1099-1110

2021

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Polyketide Synthase Modules Redefined

Angewandte Chemie International Edition, 2017-04, Vol.56 (17), p.4658-4660

Keatinge‐Clay, Adrian T.

International ed. in English, 2017

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Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.12354-12359

2014

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Engineering strategies for rational polyketide synthase design

Natural product reports, 2018-10, Vol.35 (1), p.17-181

2018

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Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

Scientific reports, 2020-08, Vol.10 (1), p.13556-13556, Article 13556

2020

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Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Nature communications, 2021-03, Vol.12 (1), p.1422-1422, Article 1422

2021

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Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (22), p.E4980-E4989

2018

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Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides

Nature biotechnology, 2022-05, Vol.40 (5), p.751-758

2022

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A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

Nature communications, 2022-10, Vol.13 (1), p.6361-11, Article 6361

2022

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The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial

Molecular plant pathology, 2011-08, Vol.12 (6), p.564-579

2011

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Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis

BMC biology, 2022-06, Vol.20 (1), p.147-147, Article 147

2022

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Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic Burkholderia Species

Angewandte Chemie (International ed.), 2012-11, Vol.51 (46), p.11611-11615

International ed. in English, 2012

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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

Automated structure prediction of trans-acyltransferase polyketide synthase products

Structure and Mechanisms of Assembly-Line Polyketide Synthases

Aromatic Polyketides from a Symbiotic Strain Aspergillus fumigatus D and Characterization of Their Biosynthetic Gene D8.t287

Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis

Polyketide reductases in defense‐related parasorboside biosynthesis in Gerbera hybrida share processing strategies with microbial polyketide synthase systems

Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl‐Substituted Aromatic Polyketides

Assessing and harnessing updated polyketide synthase modules through combinatorial engineering

Lugdunomycin, an Angucycline‐Derived Molecule with Unprecedented Chemical Architecture

Animal biosynthesis of complex polyketides in a photosynthetic partnership

Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2

Toblerols: Cyclopropanol‐Containing Polyketide Modulators of Antibiosis in Methylobacteria

Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

Insights into modular polyketide synthase loops aided by repetitive sequences

Polyketide Synthase Modules Redefined

Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases

Engineering strategies for rational polyketide synthase design

Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis

Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides

A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial

Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis

Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic Burkholderia Species

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