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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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Perspective on a chemistry classification system for AI-assisted formulation development

Journal of controlled release, 2022-12, Vol.352, p.833-839

Bolger, Michael B.

2022

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Advanced drug delivery reviews, 2001-10, Vol.50, p.S41-S67

2001

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A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

European journal of pharmaceutical sciences, 2020-12, Vol.155, p.105552-105552, Article 105552

2020

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Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary

European journal of pharmaceutics and biopharmaceutics, 2020-10, Vol.155, p.55-68

2020

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies

European journal of pharmaceutics and biopharmaceutics, 2020-11, Vol.156, p.50-63

2020

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.610-625

2017

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.626-642

2017

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Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore

Bioorganic & medicinal chemistry, 2007-07, Vol.15 (14), p.4985-5002

2007

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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.598-609

2017

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Applications of supercritical fluids to enhance the dissolution behaviors of Furosemide by generation of microparticles and solid dispersions

European journal of pharmaceutics and biopharmaceutics, 2012-05, Vol.81 (1), p.131-141

2012

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Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

Biochemical and biophysical research communications, 1998-09, Vol.250 (1), p.103-107

1998

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Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Journal of controlled release, 1999-11, Vol.62 (1-2), p.129-140

1999

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Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

European journal of pharmacology, 1989-07, Vol.166 (2), p.325-329

1989

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The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor

European journal of pharmacology. Molecular pharmacology section, 1994-10, Vol.269 (2), p.157-163

1994

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The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABA A receptor

European journal of pharmacology. Molecular pharmacology section, 1994, Vol.269 (2), p.157-163

1994

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The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

Biological psychiatry (1969), 2023-02, Vol.93 (4), p.362-369

2023

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Characterisation of carbon paste electrodes for real-time amperometric monitoring of brain tissue oxygen

Journal of neuroscience methods, 2011-02, Vol.195 (2), p.135-142

2011

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Usefulness of clinical prediction rules for the diagnosis of venous thromboembolism: A systematic review

The American journal of medicine, 2004-11, Vol.117 (9), p.676-684

2004

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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework

Toxicology and applied pharmacology, 2007-07, Vol.222 (1), p.122-128

2007

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Outpatient therapy with low molecular weight heparin for the treatment of venous thromboembolism: a review of efficacy, safety, and costs

The American Journal of Medicine, 2003-09, Vol.115 (4), p.298-308

2003

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Identification of a surface on the β-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5

Cellular signalling, 2001-07, Vol.13 (7), p.507-513

2001

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PBPK models for the prediction of in vivo performance of oral dosage forms

Perspective on a chemistry classification system for AI-assisted formulation development

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Applications of supercritical fluids to enhance the dissolution behaviors of Furosemide by generation of microparticles and solid dispersions

Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Pathway-Based Predictive Approaches for Non-Animal Assessment of Acute Inhalation Hazard Determination

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor

The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABA A receptor

The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

Characterisation of carbon paste electrodes for real-time amperometric monitoring of brain tissue oxygen

Usefulness of clinical prediction rules for the diagnosis of venous thromboembolism: A systematic review

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework

Outpatient therapy with low molecular weight heparin for the treatment of venous thromboembolism: a review of efficacy, safety, and costs

Identification of a surface on the β-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5

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