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Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

Cell, 2014-02, Vol.156 (5), p.963-974

2014

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Chaperones in Neurodegeneration

The Journal of neuroscience, 2015-10, Vol.35 (41), p.13853-13859

2015

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The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Journal of neurochemistry, 2015-04, Vol.133 (1), p.1-13

2015

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Functional analysis of Hsp70 inhibitors

PloS one, 2013-11, Vol.8 (11), p.e78443-e78443

2013

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FKBP51 and FKBP52 in signaling and disease

Trends in endocrinology and metabolism, 2011-12, Vol.22 (12), p.481-490

2011

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Human cyclophilin 40 unravels neurotoxic amyloids

PLoS biology, 2017-06, Vol.15 (6), p.e2001336

2017

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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Nature communications, 2018-10, Vol.9 (1), p.4532-13, Article 4532

2018

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DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins

The EMBO journal, 2016-07, Vol.35 (14), p.1537-1549

2016

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Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

Nature structural & molecular biology, 2018-05, Vol.25 (5), p.384-393

2018

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Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43

The Journal of neuroscience, 2007-09, Vol.27 (39), p.10530-10534

2007

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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Molecular neurodegeneration, 2010-11, Vol.5 (1), p.45-45, Article 45

2010

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Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease

Expert opinion on therapeutic targets, 2014-10, Vol.18 (10), p.1219-1232

2014

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Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

Cell chemical biology, 2016-08, Vol.23 (8), p.992-1001

2016

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Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development

Current topics in medicinal chemistry, 2016-10, Vol.16 (25), p.2741-2752

2016

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Small heat shock protein 22 kDa can modulate the aggregation and liquid–liquid phase separation behavior of tau

Protein science, 2021-07, Vol.30 (7), p.1350-1359

2021

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A global view of Hsp90 functions

Nature structural & molecular biology, 2013-01, Vol.20 (1), p.1-4

2013

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Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

Journal of molecular biology, 2011-08, Vol.411 (3), p.614-632

2011

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Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

International journal of molecular sciences, 2019-06, Vol.20 (11), p.2738

2019

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Cellular factors modulating the mechanism of tau protein aggregation

Cellular and Molecular Life Sciences, 2015-05, Vol.72 (10), p.1863-1879

2015

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Chaperoning activity of the cyclophilin family prevents tau aggregation

Protein science, 2022-11, Vol.31 (11), p.e4448-n/a

2022

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Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

PloS one, 2012-04, Vol.7 (4), p.e35566

2012

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Nature, 2006-08, Vol.442 (7105), p.916-919

2006

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Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD

ACS chemical biology, 2018-08, Vol.13 (8), p.2288-2299

2018

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Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma

Experimental eye research, 2016-03, Vol.144, p.38-45

2016

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Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations

The Journal of biological chemistry, 2019-08, Vol.294 (34), p.12717-12728

2019

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Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

Chaperones in Neurodegeneration

The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Functional analysis of Hsp70 inhibitors

FKBP51 and FKBP52 in signaling and disease

Human cyclophilin 40 unravels neurotoxic amyloids

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development

Small heat shock protein 22 kDa can modulate the aggregation and liquid–liquid phase separation behavior of tau

A global view of Hsp90 functions

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Cellular factors modulating the mechanism of tau protein aggregation

Chaperoning activity of the cyclophilin family prevents tau aggregation

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD

Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma

Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations

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