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Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

Nature reviews. Drug discovery, 2012-04, Vol.11 (4), p.292-310

2012

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Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

The FASEB journal, 2012-12, Vol.26 (12), p.5161-5171

2012

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Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2012-08, Vol.60 (2), p.411-418

2012

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Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

Neuropsychopharmacology (New York, N.Y.), 2012-01, Vol.37 (1), p.303-304

2012

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How the HIV-1 Nucleocapsid Protein Binds and Destabilises the (−)Primer Binding Site During Reverse Transcription

Journal of molecular biology, 2008-11, Vol.383 (5), p.1112-1128

2008

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Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

Hypertension (Dallas, Tex. 1979), 2008-02, Vol.51 (2, part 2), p.460-465

2008

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Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs

Expert opinion on therapeutic targets, 2007-02, Vol.11 (2), p.145-159

2007

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Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Nature (London), 2000-02, Vol.403 (6772), p.916-921

2000

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Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice

Science (American Association for the Advancement of Science), 1999-01, Vol.283 (5400), p.401-404

1999

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Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3883-3890

2017

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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Nature (London), 1997-08, Vol.388 (6642), p.586-589

1997

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Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach

Arteriosclerosis, thrombosis, and vascular biology, 2008-03, Vol.28 (3), p.425

2008

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Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

Hypertension (Dallas, Tex. 1979), 2007-03, Vol.49 (3, Part 2 Suppl), p.625-630

2007

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Destabilization of the HIV-1 Complementary Sequence of TAR by the Nucleocapsid Protein Through Activation of Conformational Fluctuations

Journal of molecular biology, 2003-02, Vol.326 (3), p.691-700

2003

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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Nature (London), 1996-10, Vol.383 (6603), p.819-823

1996

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A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity

Analytical biochemistry, 2013-10, Vol.441 (2), p.152-161

2013

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Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours

Psychopharmacologia, 2008-02, Vol.196 (2), p.327-335

2008

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The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins

Pain (Amsterdam), 2009-01, Vol.141 (1-2), p.88-96

2009

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Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity

Journal of biomolecular screening, 2013-07, Vol.18 (6), p.726-735

2013

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Mechanisms That Prevent Template Inactivation by HIV-1 Reverse Transcriptase RNase H Cleavages

The Journal of biological chemistry, 2007-04, Vol.282 (17), p.12598-12609

2007

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Insights into the Multiple Roles of Pausing in HIV-1 Reverse Transcriptase-promoted Strand Transfers

The Journal of biological chemistry, 2007-03, Vol.282 (9), p.6222-6231

2007

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Detection and Quantification of Botulinum Neurotoxin Type A by a Novel Rapid In Vitro Fluorimetric Assay

Applied and Environmental Microbiology, 2009-07, Vol.75 (13), p.4382-4390

2009

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Molecular and Cellular Targets of the MRI Contrast Agent P947 for Atherosclerosis Imaging

Molecular pharmaceutics, 2012-04, Vol.9 (4), p.850-861

2012

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Synthetic Vpr Protein Activates Activator Protein-1, c-Jun N-terminal Kinase, and NF-κB and Stimulates HIV-1 Transcription in Promonocytic Cells and Primary Macrophages

The Journal of biological chemistry, 2005-12, Vol.280 (52), p.42557-42567

2005

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Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.9196-9205

2008

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Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

How the HIV-1 Nucleocapsid Protein Binds and Destabilises the (−)Primer Binding Site During Reverse Transcription

Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach

Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

Destabilization of the HIV-1 Complementary Sequence of TAR by the Nucleocapsid Protein Through Activation of Conformational Fluctuations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity

Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours

The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins

Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity

Mechanisms That Prevent Template Inactivation by HIV-1 Reverse Transcriptase RNase H Cleavages

Insights into the Multiple Roles of Pausing in HIV-1 Reverse Transcriptase-promoted Strand Transfers

Detection and Quantification of Botulinum Neurotoxin Type A by a Novel Rapid In Vitro Fluorimetric Assay

Molecular and Cellular Targets of the MRI Contrast Agent P947 for Atherosclerosis Imaging

Synthetic Vpr Protein Activates Activator Protein-1, c-Jun N-terminal Kinase, and NF-κB and Stimulates HIV-1 Transcription in Promonocytic Cells and Primary Macrophages

Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

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