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Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B

Journal of hepatology, 2018-03, Vol.68 (3), p.431-440

2018

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Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

Blood, 2014-08, Vol.124 (9), p.1426-1433

2014

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Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors

European journal of medicinal chemistry, 2020-04, Vol.191, p.112152, Article 112152

2020

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Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7324-7333

2013

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A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

EBioMedicine, 2019-03, Vol.41, p.244-255

2019

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Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

Anti-cancer drugs, 2013-11, Vol.24 (10), p.999-1006

Yim, Hyungshin

2013

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A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

British journal of cancer, 2014-05, Vol.110 (10), p.2434-2440

2014

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Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor

Medicinal research reviews, 2016-07, Vol.36 (4), p.749-786

2016

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GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

Gastroenterology (New York, N.Y. 1943), 2013-06, Vol.144 (7), p.1508-1517.e10

2013

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BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Clinical cancer research, 2009-05, Vol.15 (9), p.3094-3102

2009

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Discovery of Pteridine-7(8H)‑one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK)

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2694-2709

2022

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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

The Journal of pharmacology and experimental therapeutics, 2014-01, Vol.348 (1), p.96-105

2014

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Journal of hepatology, 2015-06, Vol.62 (6), p.1237-1245

2015

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The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

Journal of hepatology, 2015-08, Vol.63 (2), p.320-328

2015

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Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Nature communications, 2019-06, Vol.10 (1), p.2691-15, Article 2691

2019

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Nitrogenase Cofactor Assembly: An Elemental Inventory

Accounts of chemical research, 2017-11, Vol.50 (11), p.2834-2841

2017

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Cooption of the pteridine biosynthesis pathway underlies the diversification of embryonic colors in water striders

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.19046-19054

2019

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Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Drug delivery, 2019-01, Vol.26 (1), p.756-764

2019

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Self-assembling purine and pteridine quartets: how do π-conjugation patterns affect resonance-assisted hydrogen bonding?

Organic & biomolecular chemistry, 2020-02, Vol.18 (6), p.178-181

2020

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Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold

European journal of medicinal chemistry, 2019-12, Vol.184, p.111769, Article 111769

2019

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Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7317-7324

2014

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Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors

Bioorganic & medicinal chemistry letters, 2020-08, Vol.30 (16), p.127329-127329, Article 127329

2020

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Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

Bioorganic & medicinal chemistry, 2020-03, Vol.28 (5), p.115303, Article 115303

2020

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The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation

Organic & biomolecular chemistry, 2019-10, Vol.17 (4), p.8992-9

2019

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Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B

Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors

Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε

A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Discovery of Pteridine-7(8H)‑one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK)

Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

Nitrogenase Cofactor Assembly: An Elemental Inventory

Cooption of the pteridine biosynthesis pathway underlies the diversification of embryonic colors in water striders

Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Self-assembling purine and pteridine quartets: how do π-conjugation patterns affect resonance-assisted hydrogen bonding?

Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold

Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation

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