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Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.135-151

2020

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Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

BMC genomics, 2022-07, Vol.23 (1), p.542-15, Article 542

2022

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Extensive subclonal mutational diversity in human colorectal cancer and its significance

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (52), p.26863-26872

2019

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Optimization of DNA polymerase mutation rates during bacterial evolution

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (3), p.1154-1159

2010

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Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Archives of toxicology, 2023-08, Vol.97 (8), p.2245-2259

2023

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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Mutation research. Genetic toxicology and environmental mutagenesis, 2023-10, Vol.891, p.503669-503669, Article 503669

2023

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Risks of double-counting in deep sequencing

Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (16), p.E1560-E1560

2014

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Abstract 3147: Non-invasive detection of aristolochic acid exposure using ultra-sensitive duplex sequencing

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3147-3147

2020

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Redefining “Gold Standard”: Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing

Blood, 2019-11, Vol.134 (Supplement_1), p.2093-2093

2019

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Abstract 422: Duplex sequencing for MRD detection in acute myeloid leukemia

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.422-422

2019

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Duplex sequencing identifies genomic features that determine susceptibility to benzopyrene-induced in vivo mutations

BMC genomics, 2022-07, Vol.23 (1)

2022

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Characterization of Clonal Dynamics after Hematopoietic Cell Transplantation Using Ultra-Sensitive Duplex Sequencing

Blood, 2019-11, Vol.134 (Supplement_1), p.2483-2483

2019

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Duplex Sequencing for Ultra-Low Frequency Measurable Residual Disease Detection in Adult Acute Myeloid Leukemia

Blood, 2021-11, Vol.138 (Supplement 1), p.3475-3475

2021

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Abstract PR04: Clonal landscapes of hematologic malignancies redefined by ultrasensitive duplex sequencing

Clinical cancer research, 2020-06, Vol.26 (11_Supplement), p.PR04-PR04

2020

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Duplex Sequencing Accurately Detects Variants below 1/100,000 in Genes Recurrently Mutated in Acute Myeloid Leukemia

Blood, 2018-11, Vol.132 (Supplement 1), p.2769-2769

2018

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Abstract 3041: Duplex Sequencing detects cancer-associated mutations arising during normal aging: Clonal evolution over a century of human lifetime

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3041-3041

2017

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Abstract 4343: Development of an APC and TP53 -based duplex sequencing assay to positively predict colorectal cancer response to EGFR inhibitors

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.4343-4343

2023

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Abstract 4649: Duplex Sequencing detects rare subclonal variants that mark early carcinogenesis and preneoplastic clonal evolution

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4649-4649

2019

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Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia

Blood, 2020-11, Vol.136 (Supplement 1), p.31-32

2020

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Response to: ‘when man got his mt DNA deletions?’

Aging cell, 2014-08, Vol.13 (4), p.583-583

2014

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Abstract LB254: Accurate detection of low frequency AML-associated mutations in vitro using Duplex Sequencing with enzymatic fragmentation

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB254-LB254

2023

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Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing

Nature ecology & evolution, 2024-05, Vol.8 (5), p.1021

2024

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Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2395-2395

2016

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Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

Extensive subclonal mutational diversity in human colorectal cancer and its significance

Optimization of DNA polymerase mutation rates during bacterial evolution

Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Risks of double-counting in deep sequencing

Abstract 3147: Non-invasive detection of aristolochic acid exposure using ultra-sensitive duplex sequencing

Redefining “Gold Standard”: Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing

Abstract 422: Duplex sequencing for MRD detection in acute myeloid leukemia

Duplex sequencing identifies genomic features that determine susceptibility to benzopyrene-induced in vivo mutations

Characterization of Clonal Dynamics after Hematopoietic Cell Transplantation Using Ultra-Sensitive Duplex Sequencing

Duplex Sequencing for Ultra-Low Frequency Measurable Residual Disease Detection in Adult Acute Myeloid Leukemia

Abstract PR04: Clonal landscapes of hematologic malignancies redefined by ultrasensitive duplex sequencing

Duplex Sequencing Accurately Detects Variants below 1/100,000 in Genes Recurrently Mutated in Acute Myeloid Leukemia

Abstract 3041: Duplex Sequencing detects cancer-associated mutations arising during normal aging: Clonal evolution over a century of human lifetime

Abstract 4343: Development of an APC and TP53 -based duplex sequencing assay to positively predict colorectal cancer response to EGFR inhibitors

Abstract 4649: Duplex Sequencing detects rare subclonal variants that mark early carcinogenesis and preneoplastic clonal evolution

Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia

Umbrella Trial in Myeloid Malignancies: The Myelomatch National Clinical Trials Network Precision Medicine Initiative

Response to: ‘when man got his mt DNA deletions?’

Ultra-Accurate Assessment of Pretreatment ABL1 Kinase Domain (KD) Mutations in Patients (pts) with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Using Duplex Sequencing (DS)

Abstract LB254: Accurate detection of low frequency AML-associated mutations in vitro using Duplex Sequencing with enzymatic fragmentation

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing

Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing

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