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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Pharmaceutical research, 2024-03, Vol.41 (3), p.441-462

2024

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Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Clinical pharmacology and therapeutics, 2015-09, Vol.98 (3), p.266-287

2015

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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.324-333

2016

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical research, 2023-11, Vol.40 (11), p.2513-2523

2023

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.727-736

2013

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Membrane transporters in drug development and as determinants of precision medicine

Nature reviews. Drug discovery, 2024-04, Vol.23 (4), p.255-280

2024

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A Perspective on Efflux Transport Proteins in the Liver

Clinical pharmacology and therapeutics, 2012-11, Vol.92 (5), p.599-612

2012

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In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.95-112

2013

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Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.665-674

2014

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An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.3037-3057

2013

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Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.126-141

2013

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The complexities of hepatic drug transport: current knowledge and emerging concepts

Pharmaceutical research, 2004-05, Vol.21 (5), p.719-735

2004

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Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2021-01, Vol.109 (1), p.55-64

2021

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Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2018-09, Vol.15 (9), p.4073-4083

2018

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Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Journal of pharmaceutical sciences, 2011-09, Vol.100 (9), p.3636-3654

2011

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Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2020-05, Vol.17 (5), p.1527-1537

2020

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Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation

Antimicrobial agents and chemotherapy, 2015-07, Vol.59 (7), p.3935-3943

2015

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Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes

Drug metabolism and disposition, 2005-03, Vol.33 (3), p.388-394

2005

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Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in pharmacology, 2023-03, Vol.14, p.1147495-1147495

2023

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Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.415-423

2015

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Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug–drug interactions explored within a PBPK framework

CPT: pharmacometrics and systems pharmacology, 2024-09, Vol.13 (9), p.1513-1527

2024

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Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes

Molecular pharmacology, 2013-08, Vol.84 (2), p.182-189

2013

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Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Clinical pharmacology and therapeutics, 2014-11, Vol.96 (5), p.589-598

2014

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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.443-459

2016

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Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications

Molecular pharmaceutics, 2019-03, Vol.16 (3), p.1406-1411

2019

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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

Membrane transporters in drug development and as determinants of precision medicine

A Perspective on Efflux Transport Proteins in the Liver

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

The complexities of hepatic drug transport: current knowledge and emerging concepts

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer’s Disease

Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation

Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug–drug interactions explored within a PBPK framework

Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications

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